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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818050/
The mechanism of FITC-dextran release at pH 5.0 was mainly an acid-catalyzed degradation whereas both diffusion and pH-dependent degradation resulted in FITC-dextran release at pH 6.5. The novel polymers hold great potential as a pH-sensitive controlled drug delivery system due to their interesting phase transition behavior and biocompatibility.Author: Vivek Kumar Garripelli, Jin-Ki Kim, Ran Namgung, Won Jong Kim, Michael A. Repka, Seongbong Jo
https://www.sciencedirect.com/science/article/pii/S0168365998001515
Various approaches have been used for oral delivery of drug(s) to the colon which include time-dependent delivery, pH-dependent systems and delivery systems that utilise bacteria that colonise the colon or enzymes produced by these bacteria to effect drug release.Author: M.Zahirul I Khan, Željko Prebeg, Nevenka Kurjaković
https://www.sciencedirect.com/science/article/pii/S0142961213002329
The P1-ACA materials are therefore promising formulations for drug delivery to tumor sites. 4. Conclusion. We have developed a new drug delivery system based on a responsive amphiphilic block copolymer, P(TEGMA-co-NMAA)-b-PCL, that can self-assemble into polymeric micelles with uniform nanoscale size and exhibit pH-dependent, thermal response ...Author: Ching Yi Chen, Tae Hee Kim, Wen Chung Wu, Chi Ming Huang, Hua Wei, Christopher W. Mount, Yanqing Tia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.researchgate.net/publication/224937599_pH_Sensitive_Drug_Delivery_Systems_A_Review
pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved ...
http://sverian.sveri.ac.in/downloads/codp/DPharm/DiplomaPharmacy9-13.pdf
pH Dependent Drug Delivery System: Review Korake.S.P. SVERI’s College of Pharmacy (Poly.), Pandharpur The pH-dependent CTDDS exploit the generally accepted view that pH of the human GIT increases progressively from the stomach (pH 1-2 which increases to 4 during digestion), small intestine (pH 6-7) at the site of
https://bioinspiredmaterials.berkeley.edu/research/drug-delivery/
One interest of ours is in designing pH-sensitive delivery systems whereby delivery of a therapeutic is facilitated by reduction in pH such as is observed in the tumor interstitium or in the endosome. Recently, we developed catechol-containing polymers for pH dependent delivery of the approved anticancer drug bortezomib (Velcade®).
https://www.tandfonline.com/doi/abs/10.1517/17425247.2010.491508
Sep 25, 2008 · Importance of the field: In formulation development, weakly acidic or basic drugs pose a major challenge as the solubility depends significantly on pH of the dissolution media. This gives rise to pH-dependent drug release, as the formulation is exposed to …Author: Pallavi Bassi, Gurpreet Kaur
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806248
Nov 12, 2018 · An antitumor delivery system is designed using a chemotherapy drug and a tumor target molecule covalently linked to cerium oxide nanoparticles (nanoceria). Nanoceria have a unique redox activity in that they possess antioxidant activity at physiological pH but have an intrinsic oxidase activity at …Author: Ruijuan Gao, Ruijuan Gao, Rajendra Narayan Mitra, Min Zheng, Kai Wang, Jesse Christine Dahringer, Zo...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/slct.201902909
Dopamine Loaded SiO 2 Coated Fe 3 O 4 Magnetic Nanoparticles: A New Anticancer Agent in pH‐Dependent Drug Delivery Dr. Chaitali Dey. Centre for Research in Nanoscience & Nanotechnology, University of Calcutta, Block-JD-2, Sector-III, Salt Lake, Kolkata-, 700106 India.Author: Chaitali Dey, Arpita Das, Madhuri Mandal Goswami
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