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https://www.sciencedirect.com/science/article/pii/S0169409X97000768
Advantages of rectal peptide and protein drug delivery The advantages for rectal delivery of drugs are summarised below: transition from columnar to stratified epithelium allows rapid absorption of many low molecular weight drugs; middle and inferior rectal veins drain into the inferior vena cava, thus avoiding first pass metab- olism; potential for absorption into the lymphatic system. due to large pore …Author: Martin Mackay, Judy Phillips, John Hastewell
https://www.sciencedirect.com/science/article/abs/pii/S0169409X97000768
Almost all therapeutic peptides and proteins are administered by injection. It has been recognised that specific regions of the gastrointestinal tract may offer potential in terms of macromolecular absorption. This paper will address the attractiveness of the colon and rectum as routes of administration for peptide and protein drugs.Author: Martin Mackay, Judy Phillips, John Hastewell
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/28/issue/2
Rectal drug delivery systems Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification Akira Yamamoto, Shozo Muranishi Pages 275-299
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · High drug DDI value indicates better colon drug delivery. Absorption of drugs from the colon is monitored by colonoscopy and intubation. Currently, gamma scintigraphy and high frequency capsules are the most preferred techniques employed to evaluate colon drug delivery systems.Author: Anil K. Philip, Betty Philip
https://www.sciencedirect.com/science/article/pii/S0163725820300656
These strategies included (1) use of absorption enhancers and protease inhibitors, (2) modification of chemical structure of peptide drugs using fatty acids, (3) use of chitosan capsules to achieve colon-specific delivery of insulin, thereby enhancing its absorption from the colon, and (4) administration of peptide and protein drugs to the lungs using absorption enhancers and to the skin using …Author: Akira Yamamoto, Hiroki Ukai, Masaki Morishita, Hidemasa Katsumi
https://advances.sciencemag.org/content/6/14/eaba0145.full
10 days ago · Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)–conjugated peptides across the enterocytic membrane and, thus, enables oral delivery of drug peptides ...
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