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https://www.sciencedirect.com/science/article/pii/B9780123849359100057
A further problem in peptide delivery to posterior ocular sites is the impermeability of the eye to even small molecules which restricts the complete transport of therapeutic molecules to the desired site. Table 5.2 summarizes the reported literature related to the ocular delivery of proteins and peptides.Author: Suresh P. Vyas, Rishi Paliwal, Shivani Rai Paliwal
https://www.ncbi.nlm.nih.gov/pubmed/29339145
Feb 15, 2018 · Ocular delivery of proteins and peptides: Challenges and novel formulation approaches. Mandal A(1), Pal D(1), Agrahari V(1), Trinh HM(1), Joseph M(1), Mitra AK(2). Author information: (1)Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S0168365918303717
POD, peptide for ocular delivery (GGG[ARKKAAKA] 4; 3.5 kDa) has been the first CPP expressly designed and developed for ocular administration from Johnson et al. with the aim to treat posterior segment diseases, particularly affecting retina.Author: S. Pescina, C. Ostacolo, I.M. Gomez-Monterrey, M. Sala, A. Bertamino, F. Sonvico, C. Padula, P. Sant...
https://www.researchgate.net/publication/322468712_Ocular_delivery_of_proteins_and_peptides_Challenges_and_novel_formulation_approaches
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145720/
Peptide for ocular delivery (POD)-mediated delivery of small and large molecules in cell culture C-POD was subsequently used to deliver a plasmid containing an expression cassette for green fluorescent protein (pEGFP) to HER cells, resulting in 49.13 ± 2.23% GFP-positive cells as determined by FACS analysis ( Figure 2c ).Author: Leslie N Johnson, Siobhan M Cashman, Rajendra Kumar-Singh
https://d2cax41o7ahm5l.cloudfront.net/cs/speaker-ppts/richard-addo-union-university-usa.pptx
Topical delivery is considered to be the best option for treatment of most ocular disorders Several peptides have been identified for treatment of ocular disorders like dry eye disease, age related macular degeneration, proliferative diabetic retinopathy, etc.
https://www.researchgate.net/publication/279427060_Ocular_Delivery_of_Peptides_and_Proteins
With respect to overcome protein and peptide ocular delivery-associated difficulties such as hydrophilicity, high MW, metabolic instability, a significant number of approaches have been applied by ...
https://www.semanticscholar.org/paper/Ocular-delivery-of-proteins-and-peptides%3A-and-novel-Mandal-Pal/2476b2b8e2ea396737243c7767c7c21f24a20bd0
Abstract The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides ...
https://www.dovepress.com/topical-ocular-delivery-to-laser-induced-choroidal-neovascularization--peer-reviewed-fulltext-article-IJN
Feb 17, 2017 · Topical ocular delivery to laser-induced choroidal neovascularization by dual internalizing RGD and TAT peptide-modified nanoparticles Yongchao Chu,1,* Ning Chen,2,* Huajun Yu,2,* Hongjie Mu,1 Bin He,1 Hongchen Hua,1 Aiping Wang,1 Kaoxiang Sun1 1School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, …Author: Yongchao Chu, Ning Chen, Huajun Yu, Hongjie Mu, Bin He, Hongchen Hua, Aiping Wang, Kaoxiang Sun
https://pubs.acs.org/doi/10.1021/mp400681n
Cell penetrating peptides in ocular drug delivery: State of the art. Journal of Controlled Release 2018, 284, 84-102. DOI: 10.1016/j.jconrel.2018.06.023. Tru Van Nguyen, Meong Cheol Shin, Kyoung Ah Min, Yongzhuo Huang, Euichaul Oh, Cheol Moon. Cell-penetrating peptide-based non …Author: Chang Liu, Lingyu Tai, Wenjian Zhang, Gang Wei, Weisan Pan, Weiyue Lu
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