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https://www.sciencedirect.com/science/article/pii/S0022354916322043
In rats such a transport is in the order of 2–3% of administered dose over a 3 h exposure period. This provides an explanation for the low bioavailability seen for nanoparticle-drug systems given nasally. In contrast, nanoparticle systems seem to be ideally suited for the delivery of nasal vaccine.Author: Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pubmed/17117404
This review discusses the possible benefits of using nanoparticles for nasal delivery of drugs and vaccines. It considers the various factors affecting particle transport across the nasal tissue. The evidence for the improved transport of drugs, such as peptides and proteins, across the nasal epithelium when formulated in a nanoparticulate system, as compared to an optimal solution …Author: Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pubmed/11251246/
Mar 23, 2001 · The blood--brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to the brain using nanoparticles.Author: Jörg Kreuter
https://www.researchgate.net/publication/6681360_Nanoparticulate_systems_for_nasal_delivery_of_drugs_A_real_improvement_over_simple_systems
Nanoparticulate technologies have enabled the delivery of peptide therapeutics via the oral, nasal and pulmonary route and numerous preclinical nano-delivery systems such as polymeric ...Author: Lisbeth Illum
https://www.sciencedirect.com/science/article/pii/S0169409X00001228
Mar 23, 2001 · The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to the brain using nanoparticles.Author: Jörg Kreuter
https://journals.sagepub.com/doi/full/10.3851/IMP1684
Dec 01, 2010 · Nanoparticulate-based systems might change the release kinetics of antivirals, increase their bioavailability, improve their efficacy, restrict adverse drug side effects and reduce treatment costs. Moreover, they could permit the delivery of antiviral drugs to specific target sites and viral reservoirs in the body.Author: David Lembo, Roberta Cavalli
https://www.nature.com/articles/nrd4333
Oct 07, 2014 · Nanoparticulate pharmaceutical drug delivery systems (NDDSs) are used in research and clinical settings to overcome several issues associated with traditional drugs, such as …Author: Vladimir P. Torchilin, Vladimir P. Torchilin
http://www.eurekaselect.com/75836/article/progress-nanoparticulate-systems-peptide-proteins-and-nucleic-acid-drug-delivery?tracking-code=4
Progress in many therapies, in particular in the therapies based on peptides, proteins and nucleic acids used as bioactive compounds, strongly depends on d...
https://www.tjpr.org/vol13_no7/2014_13_7_2.pdf
pure ebastine was more rapid than from F6, thus indicating the capability of chitosan to control drug permeation rate through sheep nasal mucosa. Conclusion: The results indicate that a mucoadhesive nanoparticulate system can be used effectively for the nasal delivery of the antihistamine, ebastine.
https://laurentianarchitecture.ca/776349/nanoparticulate-drug-delivery-systems-drugs-and-the-pharmaceutical-sciences.pdf
progress in transporter targeted strategies has been made especially with the rapid developments in nanotherapeutics nasal drug delivery system is commonly known for the treatment of local ailments like cold cough rhinitis etc efforts have been made to deliver various drugs especially peptides and proteins through nasal route for systemic use
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