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https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Jan 01, 2012 · Although delivery of the oligonucleotide conjugate by the homing peptide into the tumor endothelium and dose-dependent Id1 protein knockdown was observed, both in cells …Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.sciencedirect.com/science/article/abs/pii/S0304419X08000176
At the same time, various peptides with specific binding activity for a given cell line (cell-targeting peptides) have also been reported in the literature. One of the goals of the next years will be to optimize the tissue and cell delivery of therapeutic molecules by means of peptides which combine both targeting and internalization advantages.
https://www.nature.com/articles/nbt1201-1173
Dec 01, 2001 · Here we describe a strategy for the delivery of full-length proteins and peptides into mammalian cells, based on a short peptide carrier, Pep-1, which allows the delivery …Author: May C. Morris, Julien Depollier, Jean Mery, Frederic Heitz, Gilles Divita
https://www.sciencedirect.com/science/article/pii/S016561471200020X
Peptide-mediated delivery of therapeutic agents can be divided into three distinct classes: (i) HPs, which have no internalization properties and therefore only deliver their cargo to the cell surface (Figure 1a); (ii) peptides that are linked to a cell-penetrating peptide (CPP), which enables cargo internalization via endocytosis or pore formation (Figure 1b); and (iii) cell-penetrating homing peptides (CPHPs), …Author: Nina Svensen, Jeffrey G.A. Walton, Mark Bradley
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
peptides are synthetically conjugated, used as noncovalent complexes, or used in combination with polymer, liposomal or exosome formulation techniques. This review begins by describing the modes of action of antisense reagents and siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide
https://www.nature.com/articles/s41598-019-39211-4
The application of Peptide Nucleic Acids (PNAs), mimics of DNA lacking the sugar-phosphate backbone, for antisense/anti-gene therapy and gene editing is limited by their low uptake by cells. Currently, no simple and efficient delivery systems and methods are available to solve this open issue.
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13537
Cell‐penetrating peptides (CPPs) have been considered as potential drug delivery vectors due to their remarkable membrane translocation capacity. However, lack of specificity and extreme systemic toxicity hamper their successful application for drug delivery.
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