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https://www.nature.com/articles/nbt1201-1173
Dec 01, 2001 · In this report, we propose a new strategy for protein delivery based on a short amphipathic peptide carrier, Pep-1. This peptide carrier is able …Author: May C. Morris, Julien Depollier, Jean Mery, Frederic Heitz, Gilles Divita
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425738/
Apr 10, 2014 · However, applications of siRNA for dermatological conditions are limited by their poor permeation across the stratum corneum of the skin and low penetration into skin’s viable cells. In this study, we report the use of SPACE-peptide in combination with a DOTAP-based ethosomal carrier system to enhance skin delivery of siRNA.Author: Ming Chen, Michael Zakrewsky, Vivek Gupta, Aaron C. Anselmo, Deborah H. Slee, John A. Muraski, Samir...
https://www.ncbi.nlm.nih.gov/pubmed/11731788
A peptide carrier for the delivery of biologically active proteins into mammalian cells. Morris MC(1), Depollier J, Mery J, Heitz F, Divita G. Author information: (1)Centre de Recherches de Biochimie Macromoléculaire, UPR-1086 CNRS, 1919 Route de Mende, 34293 Montpellier, Cedex 5, France.Author: May C. Morris, Julien Depollier, Jean Mery, Frederic Heitz, Gilles Divita
https://www.sciencedirect.com/science/article/pii/S1931524419301458
Consequently, we developed a dual peptide-mediated carrier approach to enable targeted delivery of siRNAs to cancer cells via systemic delivery. 64 More specifically, because the epidermal growth factor receptor (EGFR) is frequently overexpressed in oral cancer cells, 65 we designed a second peptide, termed GE11R9, that comprised a nonmitogenic ...Author: James C. Cummings, Haiwen Zhang, Andrew Jakymiw
http://pubs.acs.org/doi/abs/10.1021/bm500169p
A challenge in the administration of peptide drugs is their often low hydrolytic stability, as well as other problems that are common to any drug treatment such as systemic distribution. There is a significant attention in the literature of protein drugs and their delivery strategies, but not many overviews are specifically dedicated to peptides.
https://link.springer.com/article/10.1007%2Fs40005-017-0374-0
Dec 12, 2017 · Peptides are small biological molecules that are attractive in drug delivery and materials engineering for applications including therapeutics, molecular building blocks and cell-targeting ligands. Peptides are small but can possess complexity and functionality as larger proteins. Due to their intrinsic properties, peptides are able to overcome the physiological and transport barriers ...Author: Debadyuti Ghosh, Xiujuan Peng, Jasmim Leal, Rashmi P. Mohanty
https://www.sciencedirect.com/science/article/pii/S0143720817305788
However, it remains a challenge to identify a simple carrier that can reduce the minimum effective dose of a drug. Development of new types of peptide cargo carriers is therefore crucial for targeted drug delivery. In this work, we have attempted to develop a new peptide carrier to …Author: Yanhua Lai, Ping Zhao, Zhan Zhang, Bai Li, Junchen Wu
https://www.fasebj.org/doi/10.1096/fj.02-0280fje
Dec 18, 2002 · 2. Internalization of the selected peptides by SKBR3. A phage displaying the LTVSPWY peptide sequence was chosen for further analysis. The binding of this phage to SKBR3 cells was abrogated by pretreatment with the synthetic peptide, indicating that binding of the phage is mediated by its displayed peptide.Author: Mohsen Shadidi, Mouldy Sioud
https://www.tandfonline.com/doi/abs/10.4161/adna.18739
We have explored the merits of a novel delivery strategy for the antisense oligomers based on cell penetrating peptide (CPP) conjugated to a carrier PNA with sequence complementary to part of the antisense oligomer.
https://www.fasebj.org/doi/abs/10.1096/fj.02-0280fje
SPECIFIC AIMSSelective delivery of nucleic acids into pathogenic cells would improve their efficacy and minimize potential adverse side effects. In contrast to larger molecules (e.g., antibodies), small peptides would represent more appropriate delivery vehicles because of their excellent tissue penetration, easy synthesis and as well as conjugation to drugs and short oligonucleotides.Author: Mohsen Shadidi, Mouldy Sioud
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