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https://www.tandfonline.com/doi/full/10.1080/17425247.2019.1614911
May 22, 2019 · Peptide-drug conjugates have been produced by the conjugation of drugs with BBB-targeting/-crossing antibodies/peptides. For efficient brain drug delivery and targeting nanoscaled multi-targeting delivery systems can be used. This box summarizes key points contained in the article.Author: Behzad Jafari, Mohammad M. Pourseif, Jaleh Barar, Mohammad A. Rafi, Yadollah Omidi
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://pubs.acs.org/doi/abs/10.1021/mp400680d
Nanoparticulate peptide delivery exclusively to the brain produces tolerance free analgesia. Journal of Controlled Release 2018 , 270 , 135-144. DOI: 10.1016/j.jconrel.2017.11.041.Author: Aikaterini Lalatsa, Andreas G. Schatzlein, Ijeoma F. Uchegbu
https://www.ncbi.nlm.nih.gov/pubmed/18270319
Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins. Nonaka N(1), Farr SA, Kageyama H, Shioda S, Banks WA. Author information: (1)Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, John Cochran Division, 915 N. Grand Blvd., St. Louis, MO 63106, USA. [email protected]: Naoko Nonaka, Susan A. Farr, Haruaki Kageyama, Seiji Shioda, William A. Banks
https://www.sciencedirect.com/science/article/pii/B9780123849359100069
This chapter highlights the significant advances in brain delivery of peptide and protein drugs made over the past three decades. While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake.Author: Christine Dufès
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110044/
Comparing AuNPs conjugated to the peptide LPFFD with unlabelled AuNPs, the authors demonstrated that the peptide conjugates improved the delivery to the brain by four-fold. However, AuNPs are still beset with a number of issues, there mechanism of clearance from the brain is still unknown and the long term effects of AuNPs on the brain have yet ...Author: Mark McCully, Macarena Sanchez-Navarro, Meritxell Teixido, Ernest Giralt
https://pubs.rsc.org/en/content/articlehtml/2016/cs/c6cs00076b
Increased delivery of IDUA into the mouse brain parenchyma was achieved by expressing it as a fusion protein with ApoE (159–167) 2 in mouse liver. 82 The fusion of ApoE peptide increased 3.6-fold the transport of IDUA in a pulse-chase assay performed on a cell-based BBB model – in this experiment the protein is incubated and, after washing ...Author: Benjamí Oller-Salvia, Macarena Sánchez-Navarro, Ernest Giralt, Meritxell Teixidó
https://www.sciencedirect.com/science/article/pii/S0968089617317273
Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to reach the brain in a non-invasive way. This article is a comprehensive review of the state-of-the-art of this emerging peptide delivery route, as well as of the challenges associated to it.Author: Eleni Samaridou, Maria José Alonso
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