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https://medicalxpress.com/news/2009-04-oral-delivery-rnai-therapeutics.html
Apr 29, 2009 · "We are very encouraged by these results, which show that oral delivery of a therapeutic dose of small, interfering RNA (siRNA) to a specific cell type in an animal model is possible, and that ...
https://www.aquaculturealliance.org/advocate/studies-seek-oral-delivery-of-rnai-based-therapeutics-for-shrimp/
Oral delivery evaluation. In-vivo evaluations of oral RNAi therapeutics can be conducted using dsRNA in conjunction with a pathogen challenge model. However, these assays are resource-intensive and difficult to conduct reliably, and information on the partial efficacy of oral formulations can be difficult to detect. To address this problem, the ...
https://www.alnylam.com/2019/06/21/new-rnai-platform-advances-including-oral-route-of-administration-and-cns-and-ocular-delivery/
Jun 21, 2019 · New RNAi Platform Advances, Including Oral Route of Administration and CNS and Ocular Delivery Posted at 11:08h in Capella by Chris Brickley We presented new advances in our RNAi therapeutics platform, including preclinical results demonstrating oral delivery of GalNAc-conjugated small interfering RNAs (siRNAs) directed to a liver target.
https://onlinelibrary.wiley.com/doi/full/10.1002/ps.4407
Jul 29, 2016 · However, the efficiency of RNAi is variable between different insect groups, especially by oral delivery of dsRNA. The purpose of this study is to assess the possibilities of RNAi as a tool for pest control using oral delivery of the dsRNAs encapsulated by liposome in the German cockroach Blattella germanica , which is highly sensitive to RNAi ...
https://stke.sciencemag.org/content/2/69/ec155.abstract
The ability to down-regulate gene expression specifically through the use of silencing RNA (siRNA) techniques has revolutionized biology. Now Aouadi et al. report the development of oral delivery vehicles for siRNA in mammals.Noting that M cells in Peyer’s patches of the intestine will transfer micrometer-sized β1,2-D-glucan particles to gut-associated lymphatic tissues, where the particles ...
https://www.jove.com/video/57385/practical-use-rna-interference-oral-delivery-double-stranded-rna
The oral delivery of dsRNA is particularly interesting for the application of RNAi in a pest control strategy, but a method to retard the degradation of dsRNA by the nucleases in the midgut has not yet been developed, which would have the potential to ensure effective RNAi through feeding.
https://www.sciencedaily.com/releases/2009/04/090429132236.htm
Oral Delivery System For RNAi Therapeutics Date: May 5, 2009 Source: University of Massachusetts Medical School Summary: Researchers have developed a novel approach to the delivery of small bits ...
https://academic.oup.com/jinsectscience/article/13/1/69/1074462
For some insects, ingested dsRNA fails to induce RNAi (Rajagopal et al. 2002; Terenius et al. 2011), but in three studies examining RNAi in dipterans, oral delivery was facilitated by using either a lipid-based transfection reagent (Whyard et al. 2009; Cancino-Rodezno et al. 2010) or chitosan nanoparticles to stabilize the dsRNAs (Zhang et al ...
http://publish.illinois.edu/cheng-research-group/files/2017/05/2013-Lichen-Supramolecular_ftp.pdf
vivo RNAi efficiency and anti-inflammatory effect of orally delivered siRNA. To address the dearth of techniques for oral siRNA delivery, here we report the design of supramolecular self-assembled nanoparticles (SSNPs) that are able to overcome the absorption and transfection barriers posed by …
https://www.sciencedirect.com/science/article/pii/S0142961215006900
To our knowledge, few investigations concerning oral delivery of shRNA for cancer therapy have been reported. Following oral delivery of shRNA, whether to maintain structural stability, dissociate from the vehicles in time, and effectively permeate across intestinal epithelia, were closely related to successful RNAi.
https://www.frontiersin.org/articles/10.3389/fphys.2017.00256/full
Apr 28, 2017 · Keywords: insect pest, oral dsRNA delivery, gut nucleases, PTD-DRBD, dsRNA protection, RNA interference (RNAi) Citation: Gillet F-X, Garcia RA, Macedo LLP, Albuquerque EVS, Silva MCM and Grossi-de-Sa MF (2017) Investigating Engineered Ribonucleoprotein Particles to Improve Oral RNAi Delivery in Crop Insect Pests. Front.
https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Engineered RNA seems stable enough to survive even the hostile acidic environment of the stomach, possibly enabling oral delivery of RNAi therapeutics, say Alnylam.
https://researchers.dellmed.utexas.edu/en/publications/oral-delivery-of-small-rna-and-dna
The promise of short RNA or DNA segments such as siRNAs, antisense oligonucleotides, and transcription factor decoys to treat disease has prompted nearly 40 clinical trials for RNA interference (RNAi)-based therapeutics and more than 100 clinical trials for antisense oligonucleotide-based technologies; in fact, there are promising in vivo and preclinical studies for many hundreds of …
https://www.researchgate.net/publication/26296131_Oral_delivery_of_siRNA_and_antisense_oligonucleotides
Oral delivery of siRNA and antisense oligonucleotides. ... systemic delivery of RNA via the oral route is difficult to achieve due to rapid degradation and poor transcytosis across the mammalian gut.
https://www.researchgate.net/publication/331272050_Phenotypic_Effects_of_PBAN_RNAi_Using_Oral_Delivery_of_dsRNA_to_Corn_Earworm_Lepidoptera_Noctuidae_and_Tobacco_Budworm_Larvae
Phenotypic Effects of PBAN RNAi Using Oral Delivery of dsRNA to Corn Earworm (Lepidoptera: Noctuidae) and Tobacco Budworm Larvae Article in Journal of Economic Entomology 112(1):434-439 ...
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