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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044408/
Feb 22, 2011 · Our results provide direct evidence that oral delivery of M1GS RNA by Salmonella-based vectors effectively inhibits viral gene expression and replication in mice. Moreover, this study demonstrates the utility of Salmonella-mediated oral delivery of RNase P ribozyme for gene-targeting applications in vivo.Author: Yong Bai, Hao Gong, Hongjian Li, Gia-Phong Vu, Sangwei Lu, Fenyong Liu
https://www.ncbi.nlm.nih.gov/pubmed/21300908
Feb 22, 2011 · Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice. Bai Y(1), Gong H, Li H, Vu GP, Lu S, Liu F. Author information: (1)Program in Comparative Biochemistry, and School of Public Health, University of California, Berkeley, CA 94720, USA.Author: Yong Bai, Hao Gong, Hongjian Li, Gia-Phong Vu, Sangwei Lu, Fenyong Liu
https://www.researchgate.net/publication/49817108_Oral_delivery_of_RNase_P_ribozymes_by_Salmonella_inhibits_viral_infection_in_mice
Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice Article (PDF Available) in Proceedings of the National Academy of Sciences 108(8):3222-7 · February 2011 with 50 ...
https://www.nature.com/articles/s41598-018-31303-x
Sep 03, 2018 · Drug delivery through the oral route of administration is the most common and acceptable systems due to their non-invasive and cost-effective properties.Author: Omar S. Abu Abed, Cheng Chaw, Lee Williams, Amal A. Elkordy
https://www.jove.com/video/57390/double-stranded-rna-oral-delivery-methods-to-induce-rna-interference
Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects Saikat Kumar B. Ghosh 1 , Wayne B. Hunter 2 , Alexis L. Park 1 , Dawn E. Gundersen-Rindal 1Author: Saikat Kumar B. Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen-Rindal
https://digitalassets.lib.berkeley.edu/etd/ucb/text/Bai_berkeley_0028E_11113.pdf
study provided the first direct evidence that oral delivery of M1GS RNA by Salmonella-based vectors effectively inhibits viral gene expression and replication in mice. Moreover, this study demonstrates the utility of Salmonella-mediated oral delivery of RNase P ribozyme for gene targeting applications in vivo.
https://www.sciencedirect.com/science/article/pii/S0142961213000495
Upon identifying the challenges for oral siRNA delivery, we rationally develop multifunctional MTC NPs that surmount various extracellular and intracellular barriers to promote siRNA mediated gene silencing in vitro and in vivo. This is convincing evidence that polymeric NPs were applied to systemic siRNA delivery via the oral route.Author: Chunbai He, Lichen Yin, Cui Tang, Chunhua Yin
https://www.researchgate.net/publication/319696392_Oral_siRNA_Delivery_to_Treat_Colorectal_Liver_Metastases
Convenient multiple dosing makes oral administration an ideal route for delivery of therapeutic siRNA. However, hostile GI environments and non-specific biological trafficking prevent from ...
https://digitalassets.lib.berkeley.edu/etd/ucb/text/Reeves_berkeley_0028E_18772.pdf
RNase P Catalytic RNA as a Tool for Anti-Viral Therapy By Michael A. Reeves Doctor of Philosophy in Comparative Biochemistry University of California, Berkeley Professor Fenyong Liu, Chair Engineered RNase P-based gene-targeting agents derived from the RNA subunit of E.coli RNase P, represent a promising approach for anti-viral applications.
https://www.jove.com/video/57385/practical-use-rna-interference-oral-delivery-double-stranded-rna
The oral delivery of dsRNA is particularly interesting for the application of RNAi in a pest control strategy, but a method to retard the degradation of dsRNA by the nucleases in the midgut has not yet been developed, which would have the potential to ensure effective RNAi through feeding. ... (20 mM) or RNase-free water to separate samples as ...Author: Jia-Hsin Huang, Yun Liu, Yu-Hsien Lin, Xavier Belles, How-Jing Lee
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