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https://link.springer.com/chapter/10.1007/978-1-4614-1004-1_6
Aug 03, 2011 · Abstract. This chapter reviews release mechanisms and corresponding technologies used to control drug release from oral dosage forms. Products utilizing such approaches range from simple matrix systems to those employing more complex osmotic delivery technologies. Technologies including Oros™, gastroretentive devices, TIMERx™, Contramid™, Geomatrix™,...Author: Hossein Omidian, Shahin Fesharaki, Kinam Park
https://www.researchgate.net/publication/226812777_Oral_Controlled_Delivery_Mechanisms_and_Technologies
Basic starch properties responsible for Contramid®'s slow release behavior are reviewed and used to explain the mechanism of self-assembly behind the controlled drug delivery technology.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · Since then, until the end of the 1970s, the basic understanding of controlled drug delivery was established, such as different drug release mechanisms including dissolution-, diffusion-, osmosis-, and ion exchange-based mechanisms. The technologies developed during the 1st generation were used to develop numerous twice-a-day and once-a-day oral delivery systems.Author: Kinam Park
http://kinampark.com/KPTopics/files/Drug%20Delivery,%20Oral/2011%20Omidian%2C%20Oral%20controlled%20delivery%20mechanisms%20and%20technologies.pdf
6 Oral Controlled Delivery Mechanisms and Technologies matrix at a rate depending on drug solubility and matrix permeability before release from the unit. Diffusion can also be influenced by membrane porosity if the unit is coated or by the presence of a pore-inducing filler in the coat. In such
https://www.sciencedirect.com/science/article/pii/S0168365914002508
The technologies developed during the 1st generation were used to develop numerous twice-a-day and once-a-day oral delivery systems. The same drug release mechanisms were also used to develop once-a-day and once-a-week transdermal patches. The JCR was launched at the beginning of the 2nd generation of controlled drug delivery technologies.Author: Kinam Park
https://www.springer.com/gp/book/9781461410034
Controlling the rate, extent and time of a drug’s delivery can optimize its performance in many ways, relative to “immediate release” delivery. Such optimized design requires a broad knowledge base of topics such as gastro intestinal tract physiology, polymer science, and the mechanisms by which drugs are released from the formulated units.
http://www.americanpharmaceuticalreview.com/Featured-Articles/188777-Controlled-Release-Technologies-and-Trends/
Jun 15, 2016 · An oral controlled release/delivery of microbial flora to ileum and colon for disease treatment is an unmet medical need and has significant challenges. One focus of current research is delayed release capsule technology to provide enteric protection and site delivery for targeted release applications such as fecal microbiota transplantation (FMT) to treat relapsing clostridium difficile …
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral drug delivery is the most preferred drug administration route due to convenience, cost-effectiveness, and high patient compliance. The challenges in oral drug delivery include aqueous solubility, membrane permeability, and chemical and enzymatic stability of drugs.
http://doktori.bibl.u-szeged.hu/1762/1/DISSZERTACIO.pdf
The current oral controlled delivery systems are classified as diffusion-controlled, solvent activated, or chemically controlled systems [9]. The controlled release formulations basically release the API according to three major mechanisms: diffusion, degradation, and …
https://www.researchgate.net/publication/307671765_ORAL_CONTROLLED_RELEASE_DRUG_DELIVERY_SYSTEM_AN_OVERVIEW
The aim of oral controlled release drug delivery system is to achieve better bioavailability and release the drug from the system to the target site, which should be predictable and reproducible ...
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