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http://www.jarlife.net/1201-two-methods-of-oral-delivery-of-resveratrol-a-case-study.html
Transbuccal delivery of resveratrol was obtained by placing a carboxymethylcellulose-based film containing 34 mg of resveratrol on the non-keratinized oral mucosa overnight. The second and third cycles consisted in daily ingestion of resveratrol (180 mg twice daily for cycle 2 …
https://www.ncbi.nlm.nih.gov/pubmed/26700233
Mar 01, 2016 · Despite the therapeutic effects of resveratrol, its clinical application is restricted by its poor oral bioavailability, low water solubility, and instability. Solid lipid nanoparticles (SLNs)-based drug delivery systems have been shown to provide excellent support for the delivery of hydrophobic drugs.Author: Prakash Ramalingam, Young Tag Ko
https://www.sciencedirect.com/science/article/pii/S0927776515303362
Mar 01, 2016 · Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles 1. Introduction. Resveratrol (trans-resveratrol; 3,5,4′-trihydroxystilbene),... 2. Materials and methods. CS (molecular weight, 15 kDa) was purchased from Polysciences, Inc. ...Author: Prakash Ramalingam, Young Tag Ko
https://www.researchgate.net/publication/283459750_Two_Methods_of_Oral_Delivery_of_Resveratrol_a_case_study
The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935991/
Future Applications of Oral Transmucosal Delivery of Trans-resveratrol. It remains unknown whether the benefits of tRES are dependent on intermittent peaks or sustained elevation in plasma tRES concentration, given that both exposure time to tRES and concentration influences cellular response .Author: Otis L. Blanchard, Gregory Friesenhahn, Martin A. Javors, James M. Smoliga
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049601/
Resveratrol (RES) is a natural anti-inflammatory and antioxidant compound with poor water solubility and oral bioavailability. The present study takes the advantages of nanocarriers combined with a ligand (galactose) anchoring to orally deliver RES in an attempt to improve its bioavailability and pharmacological activity.Author: Frederick Yk Siu, Shaotang Ye, Hui Lin, Shoujun Li
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