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https://www.researchgate.net/publication/11189998_Oral_Delivery_of_Proteins_Progress_and_Prognostication
The important therapeutic proteins and peptides being explored for oral delivery include insulin, calcitonin, interferons, human growth hormone, glucagons, gonadotropin-releasing hormones,...
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,13237f906e958e8d,67eb5e9723d107b6.html
The important therapeutic proteins and peptides being explored for oral delivery include insulin, calcitonin, interferons, human growth hormone, glucagons, gonadotropin-releasing hormones, enkephalins, vaccines, enzymes, hormone analogs, and enzyme inhibitors.
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The two important approaches for formulation of protein and peptides by oral route include: use of absorption enhancers and enzymatic inhibitor. Being charged, large in size and hydrophilic, proteins and peptides are notoriously poor permeators (and thus exhibit poor oral bioavailability per se).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://link.springer.com/article/10.1007/BF02976925
The major barriers to developing oral formulations for peptides and proteins are metabolic enzymes and impermeable mucosal tissues in the intestine. Furthermore, chemical and conformational instability of protein drugs is not a small issue in protein pharmaceuticals.Author: Hye J. Lee
https://www.sciencedirect.com/science/article/pii/S1359644606003084
Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery and has challenged various attempts at delivery development. Incorporation of new tools into the delivery systems that can raise membrane permeability of macromolecules is essential to attain high oral bioavailability that is acceptable in clinical applications.Author: Mariko Morishita, Nicholas A. Peppas
https://www.nature.com/articles/nrd1067
Apr 01, 2003 · Another obstacle for the oral absorption of macromolecules is their vulnerability to proteolytic degradation in the gastrointestinal tract. Most macromolecules, especially protein and peptide drugs, are susceptible to rapid degradation by digestive enzymes.Author: Michael Goldberg, Isabel Gomez-Orellana
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
Oral delivery of insulin This conjugated protein is known as hexyl insulin monoconjugate 2 (HIM2), and is the first successfully delivered oral dosage form of insulin to show good oral bioefficacy in humans. This ACE has been studied in Phase I and II clinical trials in …File Size: 228KB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023392/
Fusion of CTB to therapeutic proteins facilitates their effective oral delivery to induce oral tolerance 18,64,65,66,67 or deliver functional proteins to sera 49,50,61 or across blood–brain or retinal barriers. 62,63 However, when primed with adjuvant, CTB is highly immunogenic and diverts the specific response from the antigen of interest. 68,69 In addition, aggregation of protein antigens due to formation of CTB …Author: Kwang-Chul Kwon, Henry Daniell
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