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https://www.sciencedirect.com/science/article/pii/B9780123849649000104
Delivery of proteins and peptides across the vaginal and the rectal mucosa has poor patient compliance . Due to disadvantages of other mucosa, much attention is paid to mucosa of the oral cavity, such as buccal, gingival, and sublingual regions, and small and large intestinal mucosa for systemic delivery of proteins and peptides .Author: Gaurang Patel, Ambikanandan Misra
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in …Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ondrugdelivery.com/innovative-smart-oral-delivery-technology-proteins-peptides/
The formulation of proteins and peptides as oral dosage forms. requires advanced drug delivery strategies to overcome physiological challenges of the gastrointestinal tract, including enzymatic degradation, poor permeability and large molecular size 4 and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908063/
Jun 16, 2014 · 4. Clinical application of oral proteins and peptides. Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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