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https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
To overcome these barriers, several formulation strategies are being investigated. Here, we discuss the use of enteric-coated dry emulsions, microspheres, liposomes and nanoparticles for oral delivery of peptides and proteins. Emulsions protect drug from chemical and enzymatic breakdown in …
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in …Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Peptides and proteins are readily metabolized in the GI tract, and the hydrophilic nature of most natural peptides restricts movement across the epithelial barrier. Advances in the oral delivery of proteins and peptides have been made by the use of absorption enhancers, enzyme inhibitors and direct structural modification of the therapeutic.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
Tremendous efforts have been dedicated over numerous decades to delivery of peptides by the oral route, and a plethora of different strategies have been proposed aimed at improving the permeation of the peptide through the intestinal membrane, protecting it against enzymatic degradation and the harsh environment of the GI tract.
https://www.researchgate.net/publication/338141657_Materials_for_oral_delivery_of_proteins_and_peptides
Oral delivery of proteins and peptides is one of the main challenges in pharmaceutical drug development. Microdevices have the possibility to protect the therapeutics until release is desired ...
https://www.nature.com/articles/s41551-019-0465-5
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we ...Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
https://www.sciencedirect.com/science/article/pii/B9780123849649000104
Delivery of proteins and peptides across the vaginal and the rectal mucosa has poor patient compliance . Due to disadvantages of other mucosa, much attention is paid to mucosa of the oral cavity, such as buccal, gingival, and sublingual regions, and small and large intestinal mucosa for systemic delivery of proteins and peptides .Author: Gaurang Patel, Ambikanandan Misra
https://www.mdpi.com/1420-3049/25/5/1161
An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.Author: Sarah L. Perry, David Julian McClements, David Julian McClements
https://www.researchgate.net/publication/258149324_Properties_and_formulation_of_oral_drug_delivery_systems_of_protein_and_peptides
The present review has elaborated the biopharmaceutical challenges for the oral delivery of therapeutic proteins and peptides as well as presented a novel approach to deliver the essential ...
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