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https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.nature.com/articles/s41551-019-0465-5
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we ...Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
http://protalix.com/technology/orally-delivered-proteins/
Orally delivered proteins provide more convenient drug administration than some of the current delivery options for proteins, which include intravenous infusions and intra-muscular and subcutaneous injections. An oral delivery solution is expected to result in better patient compliance along with increased quality of …
https://www.sciencedirect.com/science/article/pii/S1381514810001768
Through the years, various strategies have been tried for improving bioavailability of therapeutic proteins. The approaches commonly used in formulating oral protein delivery systems include using specific excipients, such as absorption enhancers, enzyme inhibitors, and mucoadhesive polymers, and using formulations allowing protection of protein drugs from the harsh environment in the GI tract ...Author: Kyeongsoon Park, Kyeongsoon Park, Ick Chan Kwon, Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in …Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
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