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https://www.researchgate.net/publication/45424044_Oral_delivery_of_protein_drugs_Driver_for_personalized_medicine
Oral delivery of protein drugs: Driver for personalized medicine? ... the oral route as a portal for protein drug entry to the systemic circulation. As a site for drug delivery, the oral route ...
https://www.caister.com/cimb/abstracts/v13/13.html
Oral Delivery of Protein Drugs: Driver for Personalized Medicine? Günter Müller The pathogenesis of common diseases, such as metabolic diseases, is caused by the complex and individual interplay of many susceptibility genes, which necessitates both personalized diagnosis and therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo aggregation, adsorption, and denaturation 12,13. Consequently, the absolute …
https://www.sciencedirect.com/science/article/pii/S0378517310008331
Oral drug delivery is still the most important and most frequently used application route. Therefore, suitable oral dosage forms with the option for individualized dosing are urgently needed. This review is focusing on solid and liquid drug dosage forms enabling individual dosing for oral administration.Author: Klaus Wening, Jörg Breitkreutz
https://www.future-science.com/doi/10.4155/tde.12.143
Jan 23, 2013 · Drug carriers for oral delivery of peptides and proteins: accomplishments and future perspectives. Catarina Pinto Reis. * Author for correspondence. Universidade Lusófona (CBIOS – Laboratory of Nanoscience & Biomedical Nanotechnology), Campo …Author: Catarina Pinto Reis, Catarina Silva, Nuno Martinho, Catarina Rosado
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
DRUG FORMULATION & DELIVERY. Innovations in Pharmaceutical Technology 109. Oral delivery of insulin This conjugated protein is known as hexyl insulin monoconjugate 2 (HIM2), and is the first successfully delivered oral dosage form of insulin to show good oral bioefficacy in humans.File Size: 228KB
https://www.mdpi.com/1420-3049/25/5/1161
The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides. There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes ...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023392/
(a) Oral delivery of bioencapsulated protein drugs: Step 1, The plant cell wall protects PDs from acids and enzymes in the stomach; Step 2, Digestion of the plant cell wall by gut microbes and release...Author: Kwang-Chul Kwon, Henry Daniell
https://www.mdpi.com/1999-4923/11/2/78
Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action. C10 acts via openings of epithelial tight junctions and/or membrane ...Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
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