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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023392/
(a) Oral delivery of bioencapsulated protein drugs: Step 1, The plant cell wall protects PDs from acids and enzymes in the stomach; Step 2, Digestion of the plant cell wall by gut microbes and release...Author: Kwang-Chul Kwon, Henry Daniell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
A new gastrointestinal mucoadhesive patch system (GI-MAPS) has been designed for the oral delivery of protein drugs 60. The system consists of four layered films contained in an enteric capsule. The backing layer is made of a water-insoluble polymer, ethyl cellulose (EC).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769795/
Mechanism of oral drug delivery. An advantage of using plants to produce biologics is that the plant cell wall protects expressed protein drugs from acids and enzymes in the stomach via bioencapsulation.Author: Kwang-Chul Kwon, Henry Daniell
http://news.mit.edu/2019/orally-deliver-drugs-injected-1007
Oct 07, 2019 · Langer and Traverso have previously developed several novel strategies for oral delivery of drugs that usually have to be injected. Those efforts include a pill coated with many tiny needles, as well as star-shaped structures that unfold and can remain in …
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)33585-7
Aug 01, 2016 · Proteins drugs produced in current manufacturing systems are mostly delivered by injection; oral delivery is not possible due to drug degradation by stomach acids, proteases in the digestive system and the inability to cross intestinal membrane barriers.Author: Kwang-Chul Kwon, Henry Daniell
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
oral administration of protein and peptide drugs are the same, that is, to avoid enzymatic degradation in the digestive system, and to improve the drug oral bioavailability (23). Mucus Barrier Mucus is composed of mucin, enzymes, electrolytes, and water, which acts as a …Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
formulated protein or peptide drugs may be administered by the oral route with retention of sufficient biological activity for their therapeutic use. Strategies for oral delivery Formulating for delivery through the gastrointestinal (GI) tract requires a multitude of strategies. The dosage form must initially stabilise the drug…File Size: 228KB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Oral delivery is the preferred route of drug administration, as the majority of patients see it as the most convenient way to take their drugs . Drugs taken by the oral route have the highest level of patient compliance due to the ease and simplicity of taking medications [ 11 , 12 ].Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The two important approaches for formulation of protein and peptides by oral route include: use of absorption enhancers and enzymatic inhibitor. Being charged, large in size and hydrophilic, proteins and peptides are notoriously poor permeators (and thus exhibit poor oral bioavailability per se).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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