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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo ...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery systems for proteins and peptides are still in development stages. Oral delivery, being non-invasive, is the most favored route of drug administration. This is illustrated by the fact that oral delivery represents approximately US$ 25 billion worldwide (Werle et al., 2007).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
http://protalix.com/technology/orally-delivered-proteins/
Orally delivered proteins provide more convenient drug administration than some of the current delivery options for proteins, which include intravenous infusions and intra-muscular and subcutaneous injections. An oral delivery solution is expected to result in better patient compliance along with increased quality of …
https://www.nih.gov/news-events/nih-research-matters/bone-building-protein-delivered-orally-mice-using-plants
A team led by Dr. Henry Daniell from the University of Pennsylvania has been testing plants as an oral delivery system for protein-based drugs. In a new study, they engineered the gene for a novel form of IGF-1 into the chloroplasts of lettuce plants. Chloroplasts, which convert sunlight into food for plants, pass through the stomach unharmed.
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
protein polypeptide drug. BARRIERS TO ORAL DELIVERY OF PROTEIN AND PEPTIDE DRUG NPS Most of the protein and peptide drugs are macromolec-ular hydrophilic, in the extreme environment of gastrointes-tinal stability, susceptible to gastric acid and pepsin degradation; at the same time, because of its hydrophilicity,Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023392/
The first direct evidence for oral delivery of a CTB fusion protein produced in plants was provided by Limaye et al. (2006). 39 Pentameric assembly of CTB within chloroplasts was confirmed by immunoblot analysis and GM1 binding assays. 21 In mice fed with CTB-GFP-expressing plant cells, fluorescence microscopy showed delivery of GFP to ...Author: Kwang-Chul Kwon, Henry Daniell
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