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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Umesh Gupta, Omathanu Perumal, in Natural and Synthetic Biomedical Polymers, 2014. 15.5.1.2 Oral Drug Delivery. Oral drug delivery is the most preferred drug administration route due to convenience, cost-effectiveness, and high patient compliance. The challenges in oral drug delivery include aqueous solubility, membrane permeability, and chemical and enzymatic stability of drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967137/
6.1. Oral Delivery. The formulation of drug NCs can impressively improve the bioavailability of orally administered poorly soluble drugs. Whenever a quick onset of a poorly soluble drug is desired, the formulation of drug NCs can be favorable, for example, in case of analgesics.Author: Kavita Joshi, Akhilesh Chandra, Keerti Jain, Sushama Talegaonkar
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.8b00488
Jul 09, 2018 · Ordered mesoporous silica materials have shown great potential as oral drug delivery systems for poorly soluble drugs. However, the ability of these delivery systems to generate drug supersaturation has not been widely investigated, and the recently noted phenomenon of incomplete drug release is not well understood. Therefore, the aim of this study was to comprehensively evaluate the …Author: Tahnee Jade Dening, Lynne S. Taylor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888743/
Dec 26, 2013 · Various strategies have been widely investigated to enhance the bioavailability of poorly absorbed drugs in order to increase their clinical efficacy when administered orally. It is estimated that between 40% and 70% of all new chemical entities identified in drug discovery programs are insufficiently soluble in aqueous media [1, 2].Author: Shweta Gupta, Rajesh Kesarla, Abdelwahab Omri
https://www.sciencedirect.com/science/article/pii/S2211383513000919
The therapeutic efficacy of a poorly water soluble drug can be improved by increasing its gastrointestinal solubilization with concomitant modification of pharmacokinetic profiles. Lipid-based drug delivery systems play an important role in the delivery of hydrophobic drugs with low bioavailability by using various lipids as carriers.Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/jphp.12948
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review Sandra Jankovica,b, Georgia Tsakiridouc,d, Felix Ditzingera,b, Niklas J. Koehle, Daniel J. Pricef,g, Alexandra-Roxana Iliee,h, Lida Kalantzic, Kristof Kimpei, Rene Holmh, Anita Nairf, Brendan Griffine, Christoph Saalf and Martin KuentzbAuthor: Sandra Jankovic, Sandra Jankovic, Georgia Tsakiridou, Felix Ditzinger, Felix Ditzinger, Niklas J. Ko...
https://drug-dev.com/eyesol-a-novel-topical-ocular-drug-delivery-system-for-poorly-soluble-drugs/
The issue of poorly water-soluble drugs is well known in the scientific community, resulting in the BCS classification system for oral drug delivery.6 In short, a drug is considered poorly soluble if the required dose is not dissolved in 250 milliliters of aqueous medium.
https://www.slideshare.net/sagarsavale1/oral-drug-delivery-system-odds
May 29, 2016 · Oral drug delivery system (ODDS) ... (1+10pKa-pH ) if a poorly soluble drug was consider as a suitable candidate for formulation into sustained release system. ... part of the GIT. Drugs that are less soluble or are degraded by the alkaline pH. They encounters at the lower part of GIT. Drugs that are absorbed due to variable gastric emptying ...
https://www.researchgate.net/publication/312404938_Chapter_5_Oral_Delivery_of_Poorly_Soluble_Drugs_Dissolution_and_Drug_Release
Chapter 5 Oral Delivery of Poorly Soluble Drugs: Dissolution and Drug Release ... while 40% of currently marketed drugs are poorly soluble based on the definition of the biopharmaceutical ...
https://www.researchgate.net/publication/304897146_Bioavailability_enhancement_of_poorly_soluble_drugs_by_SMEDDS_A_review
Jan 15, 2013 · Bioavailability enhancement of poorly soluble drugs by SMEDDS: A review ... The oral delivery of lipophilic drugs presents a major . challenge bec ause of the low aqueo us solubility.
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