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https://www.sciencedirect.com/science/article/pii/S0928098719302301
Poorly water-soluble drugs present ongoing challenges with their translation into viable medicinal products. The hurdles to their successful oral delivery are a complex web of physical-chemical, biological, physiological and anatomical factors that act independently and in concert to limit drug …Author: Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augus...
https://www.ncbi.nlm.nih.gov/pubmed/29317226
Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.Author: Xue-Qing Chen, Theresa Ziemba, Christine Huang, Ming Chang, Carrie Xu, Jennifer X. Qiao, Tammy C. Wa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/
Aug 24, 2015 · The study showed that the oral bioavailability of proliposomes was enhanced in New Zealand rabbits and thereby provided a new delivery platform to enhance the absorption of poorly soluble drugs in the GIT104. Therapeutic benefits of proliposomes include enhanced bioavailability, protection of drugs from degradation in the GIT, reduced toxicity and taste masking.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.researchgate.net/publication/312404938_Chapter_5_Oral_Delivery_of_Poorly_Soluble_Drugs_Dissolution_and_Drug_Release
Chapter 5 Oral Delivery of Poorly Soluble Drugs: Dissolution and Drug Release ... while 40% of currently marketed drugs are poorly soluble based on the definition of the biopharmaceutical ...
https://www.sciencedirect.com/science/article/pii/S0169409X96004942
The enhancement in oral bioavailability of a hydrophobic amine antimalarial, prepared as an oleic acid solution in a soft gelatin capsule, is typical of the situation where formulation of a poorly water soluble drug in lipid can provide effective oral delivery.Author: Andrew J. Humberstone, William N. Charman
https://www.pharmaexcipients.com/petrochemicals/polymeric-microbeads-bioavailability/
Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug. A well-designed drug delivery platform improves the pharmacological properties of therapeutics. Here, we report a biodegradable interpenetrating polymer network (IPN) microbeads delivery technology developed by crosslinking a polymer blend of ...
https://www.sciencedirect.com/science/article/pii/S2211383513000919
The therapeutic efficacy of a poorly water soluble drug can be improved by increasing its gastrointestinal solubilization with concomitant modification of pharmacokinetic profiles. Lipid-based drug delivery systems play an important role in the delivery of hydrophobic drugs with low bioavailability by using various lipids as carriers.Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888743/
Dec 26, 2013 · In some investigations, solid self-emulsifying drug delivery systems (solid-SEDDS) were prepared by means of a wet granulation process in a lab-scale high shear mixer in order to improve the dissolution rate of a poorly water-soluble drug.Author: Shweta Gupta, Rajesh Kesarla, Abdelwahab Omri
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