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https://www.pharmasalmanac.com/articles/advances-in-the-oral-delivery-of-peptides
Oral delivery of biologics, including peptides, remains a significant challenge. 1,2 The hydrophilicity of peptides is one issue. These molecules have poor solubility in water, which makes it difficult to achieve the levels of absorption necessary for any therapeutic effect.
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Oral delivery of proteins and peptides is the most efficient way to replace the invasive route as well as a very interesting and promising area for research.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
The main issue in the development of peptide therapeutics for oral delivery is the low and variable oral bioavailability. More precisely, the oral route shows a very low absolute bioavailability of …
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://www.scanaktier.se/corporate_news/press/1464504-oral-delivery-of-peptides-proteins
Oral delivery of peptides/proteins. Oral delivery of peptides/proteins 24 november 2010 ...
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
Oral delivery of insulin This conjugated protein is known as hexyl insulin monoconjugate 2 (HIM2), and is the first successfully delivered oral dosage form of insulin to show good oral bioefficacy in humans. This ACE has been studied in Phase I and II clinical trials in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Although oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract. Therefore, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to facilitate oral peptide delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.ddw-online.com/therapeutics/p320747-oral-peptide-therapeutics-a-holy-grail-or-quixotic-quest.html
Against this backdrop, the oral delivery of peptides has caught the imagination of drug developers far and wide. The majority of drugs on the market today are given as a pill or capsule and, thus, represent the form most patients are accustomed to taking.
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