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https://www.researchgate.net/publication/7758839_Oral_Delivery_of_Peptide_Drugs_Barriers_and_Developments
The major barriers preventing the oral administration of a peptide or protein drug are presented by the enzymemediated peptide degradation and ensuing hydrolysis, the low permeability of intestinal...
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://www.semanticscholar.org/paper/Oral-delivery-of-peptide-drugs%3A-barriers-and-Hamman-Enslin/662e8a499f6c4b831eabab005862871845411218
A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs. Attempts to improve the oral bioavailability of peptide drugs have ranged from changing the physicochemical properties of peptide molecules to the inclusion of functional excipients in specially adapted drug delivery systems.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Barriers to oral delivery. Oral delivery is the preferred route of drug administration, as the majority of patients see it as the most convenient way to take their drugs [11]. Drugs taken by the oral route have the highest level of patient compliance due to the ease and simplicity of taking medications [11,12].Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.tandfonline.com/doi/abs/10.3109/10717544.2013.819611
Jul 17, 2018 · Oral delivery of therapeutic proteins and peptides: a review on recent developments. Advent of recombinant technology in protein synthesis has given birth to a new range of biopharmaceuticals. These therapeutic peptides and proteins are now emerging as an imperative part of various treatment protocols especially in the cancer therapeutics.Author: Sonal Gupta, Arushi Jain, Mainak Chakraborty, Jasjeet K Sahni, Javed Ali, Shweta Dang
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://www.ondrugdelivery.com/review-oral-peptide-delivery/
However oral peptide delivery faces many hurdles such as poor absorption, poor permeability and rapid enzymatic or pH-induced degradation in the gastrointestinal tract. Various approaches have been designed to overcome these barriers including absorption enhancers,...
https://advances.sciencemag.org/content/6/14/eaba0145.full
10 days ago · The key factor that limits development of oral delivery of protein and peptide drugs is the existence of multiple physical and biological barriers in the gastrointestinal (GI) tract, including the...
https://www.nature.com/articles/nrd1067
Apr 01, 2003 · The rapid integration of new technologies by the pharmaceutical industry has resulted in numerous breakthroughs in the discovery, development and manufacturing of pharmaceutical products.Author: Michael Goldberg, Isabel Gomez-Orellana
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126357/
Aug 08, 2014 · Finally, oral bioavailability (in fact the lack thereof) is a constant discussion topic between peptide drug developers and pharma. Peptides can rarely be absorbed by the intestinal mucosa, and thus cannot serve the appealing lifestyle drug market …Author: Laszlo Otvos, John D. Wade
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