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http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · Macromolecular drugs are usually injected subcutaneously or intravenously, and only a fraction of the administered dose reaches the disease sites in the GI tract. There has been tremendous amount of research to capitalize on the potential benefits of oral delivery macromolecular drugs, which include: Better patient acceptance and adherence
https://www.sciencedirect.com/science/article/pii/S0169409X16300278
Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although several clinical pilot studies have demonstrated that the oral absorption of macromolecules is possible, the bioavailability remains generally low and variable.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://www.researchgate.net/publication/296757797_Oral_Delivery_of_Macromolecular_Drugs
Oral Delivery of Macromolecular Drugs should encourage and motivate scientists in academia and industry to move in or intensively their activities in this challenging research field of great ...
https://www.researchgate.net/publication/326425904_Oral_Delivery_of_Macromolecular_Drugs
Oral delivery of m acromolecule drugs Being able to deliver macrom olecular IBD treatments o rally would imp rove patient experience, a void systemic exposure, an d increase dru g presence at ...
https://fotheme.xyz/drug-delivery-to-the-oral-cavity-pdf/
Drug Delivery to the Oral Cavity PDF Drug Delivery to the Oral Cavity PDF Free Download Drug Delivery to the Oral Cavity PDF Drug Delivery to the Oral Cavity Ebook Content The oral cavity (OC) and its highly permeable mucosal tissues have been taken advantage of …
https://link.springer.com/book/10.1007/978-1-4419-0200-9
Oral Delivery of Macromolecular Drugs provides also an overview on special topics in oral macromolecular drug delivery such as oral immunization and gene delivery. Each of these chapters benefits from the results of various in vivo studies demonstrating the potential of …
https://www.sciencedirect.com/science/article/abs/pii/S0169409X16300278
Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although several clinical pilot studies have demonstrated that the oral absorption of macromolecules is possible, the bioavailability remains generally low and variable.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://www.ncbi.nlm.nih.gov/pubmed/16296722
The permeation of hydrophilic macromolecular drugs through the gastrointestinal (GI) mucosa can be improved by the use of thiomers. Furthermore, some thiomers exhibit improved inhibitory properties towards GI peptidases. The efficacy of thiomers in oral drug …Author: Andreas Bernkop-Schnürch, Martin H Hoffer, Krum Kafedjiiski
https://www.springer.com/gp/book/9781441901996
Oral Delivery of Macromolecular Drugs provides also an overview on special topics in oral macromolecular drug delivery such as oral immunization and gene delivery. Each of these chapters benefits from the results of various in vivo studies demonstrating the potential of …
https://www.tandfonline.com/doi/abs/10.1517/17425247.1.1.87
Sep 06, 2016 · The permeation of hydrophilic macromolecular drugs through the gastrointestinal (GI) mucosa can be improved by the use of thiomers. Furthermore, some thiomers exhibit improved inhibitory properties towards GI peptidases. The efficacy of thiomers in oral drug delivery has been demonstrated by various in vivo studies.Author: Andreas Bernkop-Schnürch, Martin H Hoffer, Krum Kafedjiiski
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