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http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · Oral Delivery of Macromolecular Drugs. Macromolecular drugs are typically injected, but oral dosage forms are being developed to improve the treatment of gastrointestinal conditions such as inflammatory bowel disease.
https://www.amazon.com/Oral-Delivery-Macromolecular-Drugs-Strategies/dp/144190199X
Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.Author: Andreas Bernkop-Schnürch
https://www.springer.com/gp/book/9781441901996
Oral Delivery of Macromolecular Drugs addresses the most critical issues for a successful oral delivery of macromolecular drugs by a detailed characterisation of the ‘enemy’s strength’ which is mainly based on the enzymatic barrier, the mucus gel barrier and the absorption barrier. Each of these barriers is described in detail in separate chapters by leading scientists in the field.
https://link.springer.com/book/10.1007/978-1-4419-0200-9
Oral Delivery of Macromolecular Drugs addresses the most critical issues for a successful oral delivery of macromolecular drugs by a detailed characterisation of the ‘enemy’s strength’ which is mainly based on the enzymatic barrier, the mucus gel barrier and the absorption barrier. Each of these barriers is described in detail in separate chapters by leading scientists in the field.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X16300278
Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although several clinical pilot studies have demonstrated that the oral absorption of macromolecules is possible, the bioavailability remains generally low and variable.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://www.pharmaexcipients.com/oral-excipients/oral-delivery-of-macromolecular-drugs/
Jul 30, 2018 · Macromolecular drugs are usually injected subcutaneously or intravenously, and only a fraction of the administered dose reaches the disease sites in the GI tract. There has been tremendous amount of research to capitalize on the potential benefits of oral delivery macromolecular drugs, which include: Better patient acceptance and adherence
https://www.ncbi.nlm.nih.gov/pubmed/26826437
Jun 01, 2016 · Since the first attempt to administer insulin orally in humans more than 90years ago, the oral delivery of macromolecular drugs (>1000g/mol) has been rather disappointing. Although several clinical pilot studies have demonstrated that the oral absorption of macromolecules is possible, the bioavailability remains generally low and variable.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://pubs.acs.org/doi/pdf/10.1021/bk-2006-0923.ch006
Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Emisphere has developed specific molecules of low molecular weight (named "delivery agents") to facilitate the gastrointestinal (GI) absorption, and the subsequent delivery of macromolecules.
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