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https://www.ncbi.nlm.nih.gov/pubmed/29582395
1. J Cardiovasc Transl Res. 2018 Jun;11(3):192-200. doi: 10.1007/s12265-018-9802-4. Epub 2018 Mar 26. Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid-an Experimental Study.Author: Andreas Synetos, Konstantinos Toutouzas, Maria Drakopoulou, Iosif Koutagiar, George Benetos, Rafail ...
https://www.sciencedirect.com/science/article/pii/S1773224711500395
Zoledronic acid, a new highly potent third generation aminobisphosphonate, is the drug currently used to prevent bone resorption in patients with bone metastases. Moreover, ZOL is a potent inducer of apoptosis in several cancer cell types, suggesting a direct anti-cancer activity that may affect a …
https://www.blinkhealth.com/reclast
Zoledronic acid is also used to treat bone loss (osteoporosis) in men and in women after menopause who are at high risk of having broken bones (fractures). It may also be used to treat or prevent osteoporosis in people who are taking corticosteroid medications (such as prednisone) for long periods.
https://www.researchgate.net/publication/235658584_Liposome_Encapsulation_of_Zoledronic_Acid_Results_in_Major_Changes_in_Tissue_Distribution_and_Increase_in_Toxicity
Liposome Encapsulation of Zoledronic Acid Results in Major Changes in Tissue Distribution and Increase in Toxicity. Article in Journal of Controlled Release 167(3) · February 2013 with 45 Reads
https://www.blinkhealth.com/zoledronic-acid
Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur with multiple myeloma and other types of cancer (such as breast, lung) that have spread to the bones. Zoledronic acid belongs to a class of drugs known as bisphosphonates.
https://www.researchgate.net/publication/318668440_Lipid_Bilayer-Gated_Mesoporous_Silica_Nanocarriers_for_Tumor-Targeted_Delivery_of_Zoledronic_Acid_in_Vivo
PDF Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. ... However, to address the multifaceted drug delivery ...
https://www.pharmacy.com.bd/product/medicines/aclasta-4mg-vial
Hypercalcemia of malignancy: The maximum recommended dose of Zoledronic Acid in hypercalcemia of malignancy (serum calcium 12 mg/dl or 3.0 mmol/l) is 4 mg.The 4 mg dose must be given as a single-dose intravenous infusion. Dose adjustment of Zoledronic Acid is not necessary in treating patients for hypercalcemia of malignancy presenting with mild-to-moderate renal impairment.
https://www.ijpsonline.com/articles/sensitive-and-rapid-rphplc-quantification-of-zoledronic-acid-in-a-hydroxyapatitebased-nanoparticles-3360.html
Zoledronic acid, nanomedicine, RP-HPLC, validation, ICH guidelines Bisphosphonates are one of the most important bone resorption inhibitor drugs, which are used extensively in the management of skeletal diseases like osteoporosis, malignant hypercalcemia, bone metastasis and Paget’s disease [ 1 - 3 ].
https://clinicaltrials.gov/ct2/show/NCT00439244
The purpose of this study is to assess the effects of zoledronic acid administered at the same time with teriparatide compared to zoledronic acid alone and teriparatide alone on bone mineral density (BMD) gain in the lumbar spine and total hip
https://www.nejm.org/doi/full/10.1056/NEJM200310233491721
To the Editor: Zoledronic acid (Zometa, Novartis Pharmaceuticals) is a potent bisphosphonate that inhibits bone resorption. In trials of treatment for bone metastases, 9 to 15 percent of the patien...
https://lgmpharma.com/apis-for-drug-delivery-systems/
APIs for Drug Delivery Systems The area that excites LGM more than anything is working with other innovation driven companies that are focused around various drug delivery technologies. ... Zoledronic Acid; Products covered by valid patents are not offered or supplied for commercial use.
https://www.rheumatology.org/Learning-Center/Medication-Guides/Medication-Guide-Zoledronic-Acid-Reclast
ZOLEDRONIC ACID (Reclast) Zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or Paget's disease. Unlike other common bisphosphonates that are taken by mouth, Reclast bypasses the stomach because it is an infusion into the bloodstream. Bone is a living tissue constantly being remodeled.
https://www.needymeds.org/generic-drug/name/zoledronic%20acid
NeedyMeds has free information on medication and healthcare costs savings programs including prescription assistance programs and medical and dental clinics.
https://www.drugs.com/zometa.html
Zometa (zoledronic acid) (sometimes called zoledronate) is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Zometa is used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of …
http://pdrweb-stg.pdr.net/drug-summary/Reclast-zoledronic-acid-437
Zoledronic acid is classified as FDA pregnancy risk category D; use should be avoided during pregnancy due to the bone resorptive effects. Zoledronic acid may cause fetal harm when administered to a pregnant woman. The drug should be avoided during pregnancy whenever possible.
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