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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
Feb 13, 2019 · Salcaprozate sodium (SNAC) and sodium caprate (C 10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules.Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action.Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
https://www.nature.com/articles/s41591-019-0598-9
A luminal unfolding microneedle injector device (LUMI) is engineered as a custom capsule capable of efficient biologic macromolecular drug delivery into the …Author: Alex Abramson, Ester Caffarel-Salvador, Vance Soares, Daniel Minahan, Ryan Yu Tian, Xiaoya Lu, David...
https://science.sciencemag.org/content/363/6427/611.full
Feb 08, 2019 · Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar ...Author: Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Mor...
https://www.catalent.com/oral-dose/oral-technologies/oral-macromolecule-delivery/
Oral Macromolecule Delivery. T. Today, most macromolecules are delivered in traditional invasive injectable formats, which often results in poor patient compliance and are therefore not the most suitable route for long-term treatment.
http://www.pharmtech.com/oral-delivery-macromolecular-drugs
Jul 02, 2018 · So far, in studies that have evaluated the potential for oral delivery (13 – 16), considerable variability has been seen in the recovery, stability, and activity of orally administered macromolecules. Clinical trials of target oral therapies for IBD have also …
https://www.catalent.com/oral-dose/softgel-technologies/oral-macromolecule-delivery/
ENABLING IV TO ORAL CONVERSION OF MACROMOLECULES. ... Currently, due to permeability, stability, and delivery challenges, the dosing of macromolecules has been traditionally delivered in an intravenous form. Intravenous drug delivery, while able to provide an optimal pharmacokinetic therapeutic profile, presents challenges such as ease of use ...
https://www.sciencedirect.com/science/article/pii/S0169409X16300278
Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although several clinical pilot studies have demonstrated that the oral absorption of macromolecules is possible, the bioavailability remains generally low and variable.Author: Elena Moroz, Simon Matoori, Jean-Christophe Leroux
https://www.mdpi.com/1999-4923/11/1/41/pdf
pharmaceutics Review Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update Sam Maher 1,*, David J. Brayden 2, Luca Casettari 3 and Lisbeth Illum 4 1 School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin 2, Ireland 2 School of Veterinary Medicine and UCD Conway Institute, University College Dublin, ...Author: Sam Maher, David J. Brayden, Luca Casettari, Lisbeth Illum
https://www.ncbi.nlm.nih.gov/pubmed/12669028
Challenges for the oral delivery of macromolecules. Goldberg M(1), Gomez-Orellana I. Author information: (1)Emisphere Technologies Inc, 765 Old Saw Mill River Road Tarrytown, New York 10591, USA. [email protected]: Michael Goldberg, Isabel Gomez-Orellana
https://www.sciencedirect.com/science/article/pii/B978032352725500006X
Thus, a better understanding of these absorption portals is beneficial in designing nanometric devices for oral delivery of macromolecules. The various transport pathways are represented in Fig. 6.1. Download : Download full-size image; Figure 6.1. Schematic representation of cellular transport pathways for oral delivery of macromolecules.Author: Sabyasachi Maiti
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