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http://www.diabetesincontrol.com/wp-content/uploads/PPT/new_insulins_and_insulin_delivery_systems_part_2.ppt
New Insulins and Insulin Delivery Systems Bruce W. Bode, MD, FACE Atlanta Diabetes Associates Atlanta, Georgia Part 2 * Title Subtitle Glucose Goals in Type 2 Diabetes Fasting < 110 mg/dL Post-meal < 140 mg/dL A1C < 6.5% Glucose Goals in Type 1 Diabetes Fasting and Premeal 70 - 140 mg/dL Post-meal < 160 mg/dL A1C < 6.5% Glucose Goals in Hospital 80 – 110 mg/dl in Surgical ICU patients 80 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
The oral route of insulin administration may be the most patient-friendly way of taking insulin and it could more closely mimic physiological insulin delivery (more portal insulin concentration than peripheral). However, the challenges in making oral insulin include: Inactivation by proteolytic enzymes in the GI tract and low permeability ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Oral insulin delivery has been an interesting and promising research field that promises to revolutionize the way diabetes mellitus is treated. Several studies have achieved some positive results, and some delivery systems are in advanced stages of development.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
http://ijpsnonline.com/Issues/1057_full.pdf
Kinesh V.P. et.al. : Novel Approaches for Oral Delivery of Insulin and Current Status of Oral Insulin Products 1059 Approaches for oral Insulin Attempted Oral Insulin Delivery Systems Most peptides are not bioavailable from the GIT after oral administration (Cho YW et al., 1989).
https://www.diabetes.co.uk/oral-insulin.html
Oral insulin is a reality: it is simply a matter of when. The realisation that insulin injections are going to have to become a part of everyday life can be extremely harrowing for many diabetics. Injection takes time, interrupts daily schedules and is considered unpleasant by many people. Children or adolescents who require daily insulin […]
https://www.slideshare.net/ankit_2408/oral-hypoglycemics-12241249
Apr 01, 2012 · Oral hypoglycemics 1. ORAL HYPOGLYCEMICS AND INSULIN Free Powerpoint Templates Page 1 2. DIABETES• A chronic metabolic disorder characterised by a high blood glucose concentration- hyperglycaemia• fasting plasma glucose > 7.0 mmol/l, or plasma glucose> 11.1 mmol/l 2 hours after a meal• caused by – insulin deficiency – insulin resistance Free Powerpoint Templates …
https://www.webmd.com/diabetes/features/insulin-delivery
Uneven insulin delivery. Because they send insulin into the body through the pores, jet injectors may not always deliver an accurate dose. Other options include an insulin patch.
https://www.oramed.com/pipeline/ormd-0801-type-2/
Oramed’s oral insulin (ORMD-0801) has the potential to create a new paradigm in the treatment of diabetes by oral delivery of insulin at an earlier stage of treatment, potentially slowing disease progression and delaying or even eliminating late-stage complications.
https://www.sciencedirect.com/science/article/pii/S1021949815000356
3.3. Modification of nanoparticles and micelles for insulin oral delivery. For insulin oral delivery, the copolymers used to form micelles should (1) quickly self-assemble in water, (2) remain stable in the gastrointestinal tract, (3) be nontoxic and biocompatible, and (4) be easy to synthesize on a large scale .Author: Milind Sadashiv Alai, Wen Jen Lin, Shailaja Suresh Pingale
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