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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146165/
Drug administration. During drug administration, the rat was loosely immobilized by a small cloth with the head and neck outside the cloth. Rats with chronic intrathecal catheters (n=6) were administered morphine at doses of 1, 3, 10 and 30 μg in 10 μL volume by a Hamilton syringe.
https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948827
Modifying well-validated techniques for intrathecal catheterization, drug delivery, and sensory assessment in the rat, we previously described an in vivo model that closely parallels clinical injury. [10] However, intrathecal catheterization induced moderate to severe morphologic damage in control animals, precluding meaningful histologic ...Author: Shinichi Sakura, Keishi Hashimoto, Andrew W. Bollen, Ricardo Ciriales, Kenneth Drasner
https://www.researchgate.net/publication/8575099_Intrathecal_Catheterization_and_Drug_Delivery_in_the_Rat
Intrathecal catheterization was performed as originally developed by Yaksh et al. and described in a recent review on IT catheterization and drug delivery in the rat [3, 38]. In brief, rats were ...
https://link.springer.com/protocol/10.1385%2F1-59259-770-X%3A011
The modified surgical method of intrathecal catheter placement, microinjection drug delivery, and behavioral parameters are described in detail. Key Words Rat intrathecal catheter spinal cord clinical observations behavior spinal pharmacology animal modelAuthor: Shelle A. Malkmus, Tony L. Yaksh
http://www.tandfonline.com/doi/pdf/10.1080/01616412.2016.1196870
A modified procedure for lumbar intrathecal catheterization in rats Yongheng Hou, Lina Wang, Jianling Gao, Xin Jin, Fuhai Ji, Jianping Yang Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, China Objectives: Intrathecal catheterization and drug delivery in rats has always been a very important method for
https://onlinelibrary.wiley.com/doi/full/10.1002/ar.22506
Catheterization, as first described by Yaksh and Rudy (Yaksh and Rudy, 1976) and later on modified by LoPachin etal. , has become the most extensively used method for rat intrathecal drug delivery (Storkson etal., 1996). Both drug administration methods are associated with …Author: Liming Chen, Meng Jiang, Lei Pei
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