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https://pdfs.semanticscholar.org/7f88/679105f94e587373c3885b41f84901916991.pdf
he topical application of acyclovir as eye ointment remains a concern for effective management of various ocular viral diseases owing to poor ocular drug bioavailability. Hence the present study was aimed to develop and evaluate nanosphere colloidal suspension containing acyclovir as potential ophthalmic drug delivery system. The acyclovir-loaded
https://www.scholarsresearchlibrary.com/articles/acyclovir-loaded-chitosan-nanoparticles-for-ocular-delivery.pdf
effectiveness of acyclovir, e.g., chemical modification of the drug [5] and its incorporation into colloidal systems such as liposomes or nanoparticles [6]. Nanoparticles have been used as ophthalmic delivery systems because they are able to penetrate into the corneal or …Author: Selvaraj. S, Saravanakumar. N, Karthikeyan. J, Deborah Evangeline. D, Lathamary.Rajendran N. N
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.researchgate.net/profile/Nayanabhirama_Udupa/publication/26829728_Controlled_release_polymeric_ocular_delivery_of_acyclovir/links/00b4952e7e0fe8d3a0000000/Controlled-release-polymeric-ocular-delivery-of-acyclovir.pdf
The aim of the present study was to formulate and evaluate controlled release polymeric ocular delivery of acyclovir. Reservoir-type ocular inserts were fabricated by sandwiching hydroxypropyl ...
https://www.researchgate.net/publication/23443683_Acyclovir_delivery_systems
Several biodegradable drug delivery systems have been proposed to enhance the ocular bioavailability of acyclovir, such as permeation enhancers, liposomes [61], and microparticles [62]. SLN ...
https://www.researchgate.net/publication/40542784_A_Novel_Approach_For_Ocular_Delivery_of_Acyclovir_Via_Niosomes_Entrapped_In_Situ_Hydrogel_System
Preperation and prop-Kapadia R etal., A Novel Approach For Ocular Delivery of Acyclovir Via Niosomes Entrapped In Situ Hydrogel System 750 Kapadia R erties of …
https://www.researchgate.net/publication/270964184_Ocular_drug_delivery_systems_An_overview
Ocular drug delivery systems: An overview Ashaben Patel , Kishore Cholkar , Vibhuti Agrahari , and Ashim K Mitra Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri ...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.7b00128
Topical drug administration for back of the eye delivery is extremely challenging due to the presence of protection mechanisms and physiological barriers. Self-assembled polymeric nanomicelles have emerged as promising vehicles for drug delivery. Apart from serving as an inert nanocarrier for therapeutic agents, polymeric nanomicelles are known to bypass mononuclear phagocytic system (MPS) and ...Author: Abhirup Mandal, Kishore Cholkar, Varun Khurana, Ankit Shah, Vibhuti Agrahari, Rohit Bisht, Dhananjay...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.researchgate.net/profile/Sudip_Das4/publication/279418971_Microparticles_and_Nanoparticles_in_Ocular_Drug_Delivery/links/5b8cd0e3299bf1d5a73a0ba4/Microparticles-and-Nanoparticles-in-Ocular-Drug-Delivery.pdf
ophthalmic drug delivery technique that may enhance dosage form accept- ability while providing sustained release in the ocular milieu (14). Particulate drug delivery consists of systems described ...
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