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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
conventional ocular drug delivery systems Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket [ 8 ] .Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pubmed/25590022
In the past two decades, ocular drug delivery research acceleratedly advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.allfordrugs.com/ocular-drug-delivery-systems-an-overview/
The existing ocular drug delivery systems are thus fair and in-efficient. The design of ocular system is undergoing gradual transition from an empirical to rational basis; Interest in the broad areas of ocular drug delivery has increased in recent years due to an increased understanding of a number of ocular physiological process and pathological conditions.
https://www.sciencedirect.com/science/article/pii/S1359644618303994
In most topical ocular drug delivery systems, the drug is dissolved in a matrix material, such as a polymer, and its solubility depends on the properties of the drug and the matrix.Author: Astrid Subrizi, Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ru...
https://www.nature.com/articles/s41433-020-0809-0
Feb 18, 2020 · Extended ocular drug delivery systems for the anterior and posterior segments: biomaterial options and applications. Expert Opin Drug Deliv 2017;14:611–20. CASAuthor: Jennifer J. Kang-Mieler, Kayla M. Rudeen, Wenqiang Liu, William F. Mieler
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500016Z
The need for an ocular drug delivery system which has the convenience of a drop, but will localize and maintain drug activity at its site of action, is apparent. Liposomes offer …Author: Dale Meisner, Michael Mezei
https://www.researchgate.net/publication/270964184_Ocular_drug_delivery_systems_An_overview
The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.
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