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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
Download full-text PDF. OCULAR DRUG DELIVERY SYSTEM – A REVIEW ... more sensitive diagnostic techniques and novel therapeutic agents continue to provide ocular delivery systems with high ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.researchgate.net/publication/270964184_Ocular_drug_delivery_systems_An_overview
The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration ...
http://www.thepharmajournal.com/vol1Issue12/Issue_feb_2013/1.1.pdf
ocular drug delivery systems are as follows: The ocular bioavailability must be increased from less than 1% to 15-20% of the administered dose. Most of the currently marketed ocular drugs were initially developed for non-ocular applications, hence their low or nonspecificity. So, there is a need to develop new drug candidates primarily
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500016Z
Various routes of administration such as topical instillation, intravitreal, subconjunctival and systemic injection are also discussed. Significant progress has been made in these areas and a complete understanding of the liposome interaction with ocular tissues should enable the design of liposomal products suitable for ocular drug delivery.Author: Dale Meisner, Michael Mezei
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
http://samples.jbpub.com/9781284025682/9781449674250_CH10.pdf
Acquire sound knowledge of various approaches to increase ocular drug absorption. Understand the utility, recent progress, and specific development issues relating to dendrimers, cyclodextrins, nanoparticles, liposomes, nanomicelles, microneedles, implants, in situ gelling systems, and contact lens in ocular drug delivery.
https://www.slideshare.net/vidyadhonde5/occular-drug-delivery-system-ppt
Jan 18, 2016 · Ocular drug delivery systems provide local as well as systemic delivery of the drugs. The novel advanced delivery systems offer more protective and effective means of the therapy for the nearly inaccessible diseases or syndromes of eyes. Controlled ocular drug delivery systems increase the efficiency of the drug by reducing its wastage and by ...
http://www.freepatentsonline.com/9895258.html
Feb 20, 2018 · Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal.Author: David Y. Badawi, Daniel O'Keeffe, Paul Badawi
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