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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997133/
Jun 08, 2018 · The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own.Author: Muhammad Farhan Sohail, Mubashar Rehman, Hafiz Shoaib Sarwar, Sara Naveed, Omer Salman, Nadeem Irfan...
https://www.dovepress.com/advancements-in-the-oral-delivery-of-docetaxel-challenges-current-stat-peer-reviewed-article-IJN
A decent number of studies have been reported for the safe and effective oral delivery of Docetaxel. These nanocarriers, including liposomes, polymeric nanoparticles, metallic nanoparticles, hybrid nanoparticles, dendrimers and so on, have shown promising results …Author: Muhammad Farhan Sohail, Mubashar Rehman, Hafiz Shoaib Sarwar, Sara Naveed, Omer Salman, Nadeem Irfan...
https://www.ncbi.nlm.nih.gov/pubmed/29922053
Jun 08, 2018 · The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own.Author: Muhammad Farhan Sohail, Mubashar Rehman, Hafiz Shoaib Sarwar, Sara Naveed, Omer Salman, Nadeem Irfan...
https://www.dovepress.com/advancements-in-the-oral-delivery-of-docetaxel-challenges-current-stat-peer-reviewed-fulltext-article-IJN
A decent number of studies have been reported for the safe and effective oral delivery of Docetaxel. These nanocarriers, including liposomes, polymeric nanoparticles, metallic nanoparticles, hybrid nanoparticles, dendrimers and so on, have shown promising results …Author: Muhammad Farhan Sohail, Mubashar Rehman, Hafiz Shoaib Sarwar, Sara Naveed, Omer Salman, Nadeem Irfan...
https://www.pnas.org/content/110/43/17498
Oct 22, 2013 · Oral drug delivery is the most convenient administration route for patients. Docetaxel, a potent anticancer drug, elicits severe side effects following intravenous administration. Furthermore, oral docetaxel absorption is prevented by biochemical barriers in the intestine.Author: Suha Attili-Qadri, Nour Karra, Alina Nemirovski, Ouri Schwob, Yeshayahu Talmon, Taher Nassar, Simon ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808655/
Oct 22, 2013 · Oral drug delivery is the most convenient administration route for patients. Docetaxel, a potent anticancer drug, elicits severe side effects following intravenous administration. Furthermore, oral docetaxel absorption is prevented by biochemical barriers in the intestine.Author: Suha Attili-Qadri, Nour Karra, Alina Nemirovski, Ouri Schwob, Yeshayahu Talmon, Taher Nassar, Simon ...
https://www.researchgate.net/publication/325649540_Advancements_in_the_oral_delivery_of_Docetaxel_challenges_current_state-of-the-art_and_future_trends
The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability, gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus, chemotherapeutic drugs, including Docetaxel, are administered via an intravenous route, which poses many disadvantages of its own.
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.920430
Context: Nanoemulsions (NE) are one of the robust delivery tools for drugs due to their higher stability and efficacy. Objectives: The purpose of present investigation is to develop stable, effective and safe NE of docetaxel (DTX). Methods: Soybean oil, lecithin, Pluronic F68, …
https://www.ncbi.nlm.nih.gov/pubmed/29597043
Jun 15, 2018 · The oral administration of a single dose of pegylated nanoparticles to mice provided sustained and prolonged therapeutic plasma levels of docetaxel for up 48-72 h. In addition, the relative oral bioavailability of docetaxel was around 32%.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894956/
Jan 13, 2014 · Oral docetaxel doses of 10–30 mg/kg were used in previous studies of the oral delivery of docetaxel. 13, 15, 37 Moreover, doc-etaxel has been reported to exhibit linear pharmacokinetics at intravenous doses of 2–20 mg/kg and oral doses of 20–100 …Author: Hyun-Jong Cho, Jin Woo Park, In-Soo Yoon, Dae-Duk Kim
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