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https://www.chemistryworld.com/news/oral-delivery-of-anticancer-drug/9124.article
The carrier also improves the oral pharmacokinetics and cell uptake, and sustains release of the drug. Tests on mice showed the efficacy of orally delivered asplatin using the new carrier is comparable to that of injected cisplatin and considerably better than that of other Pt(IV) prodrugs delivered orally without the PEGylated nanoparticles.
https://www.physiology.org/doi/abs/10.1152/ajprenal.00346.2019
Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI. Dianxiong Zou, Raghu Ganugula, Meenakshi Arora, Mary B. Nabity, David Sheikh-Hamad, and ; M. N. V. Ravi KumarAuthor: Dianxiong Zou, Raghu Ganugula, Meenakshi Arora, Mary B. Nabity, David Sheikh-Hamad, M. N. V. Ravi Ku...
https://www.thno.org/v09p6568.htm
Targeted therapy via the patient-friendly oral route remains the holy grail of chemotherapy for cancer. Herein we report a yeast-derived platform for targeted oral delivery of cisplatin (CDDP) that is one of the most effective drugs for chemotherapy of various types of cancers.
https://www.ncbi.nlm.nih.gov/pubmed/15846123
Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity. Lynch ED(1), Gu R, Pierce C, Kil J.Author: Eric D. Lynch, Rende Gu, Carol Pierce, Jonathan Kil
https://www.ncbi.nlm.nih.gov/pubmed/31532243
Nov 01, 2019 · Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI. Zou D(1), Ganugula R(1), Arora M(1), Nabity MB(2), Sheikh-Hamad D(3), Kumar MNVR(1).Author: Dianxiong Zou, Raghu Ganugula, Meenakshi Arora, Mary B. Nabity, David Sheikh-Hamad, M. N. V. Ravi Ku...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996214/
Jan 29, 2020 · Considering the specificity of the anatomical location of cervical cancer (the tumor being exposed in a natural lumen) and the role of chemotherapy as a cornerstone in its management, cervical cancer is the most suitable cancer for the investigation of sonophoresis-mediated transdermal delivery of cisplatin in clinical practice.Author: Shanshan Ma, Chang Liu, Bo Li, Tingting Zhang, Li Jiang, Rensheng Wang
http://www.eurekaselect.com/140739/article
Keywords: Cisplatin, combination delivery, drug delivery, drug resistance, prodrug, tumor therapy. Abstract: Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage.Author: Zhanguo Yue, Zhiqiang Cao
https://reference.medscape.com/drug/platinol-aq-cisplatin-342108
Ototoxicity. Cisplatin for injection can cause ototoxicity, which is cumulative and may be severe; consider audiometric and vestibular function monitoring Ototoxic effects may be more severe and detrimental in pediatric patients receiving cisplatin for injection, …
https://www.drugs.com/dosage/cisplatin.html
Sep 12, 2019 · -In combination with cyclophosphamide (give sequentially): Cisplatin 75 to 100 mg/m2 IV over 6 to 8 hours per cycle once every 4 weeks (Day 1); the dose of cyclophosphamide when used in combination with cisplatin is 600 mg/m2 IV once every 4 weeks (Day 1) Comments: -This drug should be administered by slow IV infusion.10/10
https://www.cancer.gov/research/progress/discovery/cisplatin
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. Prior to the discovery of cisplatin, men with testicular cancer had few medical options. Cisplatin is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers.
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