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https://www.sciencedirect.com/science/article/pii/S0378517301009206
In 1931, Christie and Hanzal performed the first ocular delivery of insulin and demonstrated that insulin can be absorbed via the conjunctiva membrane. In their study, insulin was prepared using a pH 2.5 buffer with 0.2% of phenol.Author: Yung Chi Lee, Pahala Simamora, Sirirat Pinsuwan, Samuel H Yalkowsky
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Trans-dermal insulin delivery eliminates the problems associated with needles and injections and large surface area of the skin makes it a convenient route for insulin delivery. However, the penetration of insulin is halted by the stratum corneum, the outer most layer of the skin.
https://arizona.pure.elsevier.com/en/publications/ocular-devices-for-the-controlled-systemic-delivery-of-insulin-in
Apr 20, 1999 · title = "Ocular devices for the controlled systemic delivery of insulin: In vitro and in vivo dissolution", abstract = "Both in vitro flow-through and in vivo device removal methods were utilized to determine the dissolution rate of insulin from a Gelfoam{\circledR} based eye device.Author: Yung Chi Lee, Samuel H Yalkowsky
https://arizona.pure.elsevier.com/en/publications/review-on-the-systemic-delivery-of-insulin-via-the-ocular-route
T1 - Review on the systemic delivery of insulin via the ocular route. AU - Lee, Yung Chi. AU - Simamora, Pahala. AU - Pinsuwan, Sirirat. AU - Yalkowsky, Samuel H. PY - 2002/2/21. Y1 - 2002/2/21. N2 - Systemic drug absorption from the ocular route is well known.Author: Yung Chi Lee, Pahala Simamora, Sirirat Pinsuwan, Samuel H Yalkowsky
https://www.ncbi.nlm.nih.gov/pubmed/9109043
An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13 eye device formulations were evaluated.Author: Yung Chi Lee, Pahala Simamora, Samuel H Yalkowsky
https://www.sigmaaldrich.com/catalog/papers/9109043
An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13 eye device formulations were evaluated.
https://www.researchgate.net/publication/11467139_Review_on_the_systemic_delivery_of_insulin_via_the_ocular_route
Systemic drug absorption from the ocular route is well known. Although there is some absorption from the conjunctival sac, the nasal meatus is the site where the majority of systemic absorption of instilled drug takes place. This article reviews the principles of systemic absorption of insulin applied topically to …
https://www.ncbi.nlm.nih.gov/pubmed/16241870/
BACKGROUND: Various insulin delivery systems have been considered for systemic absorption other than injections. Although the ocular route has been suggested, its use is limited by the amount of insulin absorbed systemically via eyes.Author: B. Xuan, D.A. McClellan, R. Moore, G.C.Y. Chiou
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