Ocular Delivery Of Nanoparticles

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Ocular Delivery of pRNA Nanoparticles: Distribution and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124000/
    Ocular Delivery After Topical Administration. No pRNA nanoparticles and dsRNA were found in the cells of conjunctiva, cornea, retina, and sclera at 12 h after topical eyedrop administration. This suggests that topical administration was not an effective ocular delivery method for both pRNA and dsRNA compared with subconjunctival injection.Author: Liang Feng, S. Kevin Li, Hongshan Liu, Chia-Yang Liu, Kathleen LaSance, Farzin Haque, Dan Shu, Peixu...

Nanotechnology Approaches for Ocular Drug Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617524/
    The toxicity of nanoparticles in ocular tissues can be affected by many factors, including the chemistry, size, dose, time of assessment, and the biodistribution pattern of the particles in the eye. ... Zimmer A, Kreuter J. Microspheres and nanoparticles used in ocular delivery systems. Adv …

Ocular delivery of solid lipid nanoparticles - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/B9780128136874000074
    Lipid Nanoparticles for Ocular Delivery. Lipid nanoparticle suspensions are mainly conceived for topical administration, and consequently for the anterior segment of the eye. In these cases, the main objective for nanoparticulate formulation is to increase retention time at the corneal surface by mucoadhesion and improve corneal permeation ...Author: Luigi Battaglia, Marina Gallarate, Loredana Serpe, Federica Foglietta, Elisabetta Muntoni, Ana del P...

(PDF) Microparticles and Nanoparticles in Ocular Drug Delivery

    https://www.researchgate.net/publication/279418971_Microparticles_and_Nanoparticles_in_Ocular_Drug_Delivery
    Microparticles and Nanoparticles in Ocular Drug Delivery 457 Fig. 5 In vitro release profiles of piroxicam microspheres M1 and M2 compared to the dissolution profile of micronized piroxicam powder.

New nanoparticles for topical ocular delivery of ...

    https://www.sciencedirect.com/science/article/pii/S0378517320300028
    Thus, this study aimed to develop and evaluate a chitosan (CS) and hyaluronic acid (HA) nanoparticulate system for topical ocular delivery of EPO. Nanoparticles were prepared by ionotropic gelation using six different HAs (HA1-HA6), and characterized by size, zeta potential (ZP), polydispersity index (Pdi), cytotoxicity and mucoadhesion.Author: Beatriz Silva, Joana Marto, Berta São Braz, Esmeralda Delgado, António José Almeida, Lídia Gonçalves

Investigations on Polymeric Nanoparticles for Ocular Delivery

    https://www.hindawi.com/journals/apt/2019/1316249/
    The nanoparticles were found to reduce the intra ocular pressure (IOP) in rabbits for prolonged period when compared to conventional eye drops. The results of the present study suggested a promising role of polymeric nanoparticles for ocular drug delivery in treatment of glaucoma.Author: Neeraj Mittal, Gurpreet Kaur

Creation of nano eye-drops and effective drug delivery to ...

    https://www.nature.com/articles/srep44229
    Mar 14, 2017 · We speculated that a nanoparticle-based brinzolamide delivery system would have a stronger ocular hypotensive effect at a lower concentration because of …Author: Yoshikazu Ikuta, Shigenobu Aoyagi, Yuji Tanaka, Kota Sato, Satoshi Inada, Yoshitaka Koseki, Tsunenob...

Human serum albumin nanoparticles for ocular delivery of ...

    https://www.researchgate.net/publication/323380925_Human_serum_albumin_nanoparticles_for_ocular_delivery_of_bevacizumab
    albumin nanoparticles as carriers for ocular delivery of bevacizumab. In. addition, this work also includes the evaluation of the cytotoxicity on.

Ocular Delivery of pRNA Nanoparticles: Distribution and ...

    https://rnanano.osu.edu/Guo/Papers/2014%20-%20Pharmaceutical%20Research%20-%20Feng%20et%20al.%20-%20Ocular%20Delivery%20of%20pRNA%20Nanoparticles%20Distribution%20and%20Clearance%20After%20Subconjunctival%20I
    of ocular drug delivery, the distribution and clearance after ocular drug delivery are still difficult to predict (16). This is partly due to the complicated anatomy and physiology of the eye. Particularly, ocular pharmacokinetics of macromolecules such as pRNA nanoparticles and their distribution and clear-

Dendrimer Nanoparticles for Ocular Drug Delivery Journal ...

    https://www.liebertpub.com/doi/10.1089/jop.2012.0232
    Mar 13, 2013 · Dendrimers are tree-like, nanostructured polymers that have received significant attention as ocular drug delivery systems, due to their well-defined size, tailorable structure, and potentially favorable ocular biodistribution. ... Nanoparticles for drug delivery to the anterior segment of the eye. Advanced Drug Delivery Reviews, Vol. 122.Author: Siva P. Kambhampati, Rangaramanujam M. Kannan

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