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https://www.ncbi.nlm.nih.gov/pubmed/29339145
Feb 15, 2018 · The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches.Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.researchgate.net/publication/322468712_Ocular_delivery_of_proteins_and_peptides_Challenges_and_novel_formulation_approaches
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large ...
https://www.sciencedirect.com/science/article/pii/B9780123849359100057
5.3. Considerations and Opportunities for Protein/Peptide Ocular Delivery. The topical delivery of therapeutic molecules is considered to be the best option for treatment of most ocular disorders , but in some cases systemic delivery of molecules has also been demonstrated.Thus, a factor which must be taken into consideration during ocular absorption of topically applied peptides and proteins ...Author: Suresh P. Vyas, Rishi Paliwal, Shivani Rai Paliwal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995646/
Feb 15, 2018 · Proteins and peptides: challenges in ocular delivery. Proteins and peptides, a class of biopharmaceuticals poses significant challenges owing to their large size, poor permeation and susceptibility to degradation. The intrinsic properties associated with the complex macromolecular nature of proteins and peptides is often required for achieving ...Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.researchgate.net/publication/279427060_Ocular_Delivery_of_Peptides_and_Proteins
The main approach to controlled local delivery of proteins and peptides to ocular sites is achieved by tailoring or manipulating their physicochemical properties without affecting their inherent ...
https://d2cax41o7ahm5l.cloudfront.net/cs/speaker-ppts/richard-addo-union-university-usa.pptx
Challenges to ocular delivery of proteins/peptides Barriers for locally delivered drugs. Loss of drug from ocular surface. Lacrimal-fluid barrier. Blood-ocular barrier. Low drug contact time. Tear production and turnover. Consequent dilution. Schematic presentation of the different barriers for ocular delivery of proteins and peptides
https://link.springer.com/chapter/10.1007/978-3-319-47691-9_8
Nov 18, 2016 · This chapter discusses the development of proteins and peptides for ocular delivery with an emphasis on their specific considerations and challenges, and a role of specific proteins such as alpha crystallins and thymosin β4 in ocular drug delivery. Possible routes …Author: Lunawati Bennett
https://www.scribd.com/presentation/259255185/Ocular-Delivery-of-peptides-and-proteins
OCULAR DELIVERY OF PEPTIDES AND. PROTEINS. RICHARD ADDO, R.Ph., Ph.D ASSOCIATE PROFESSOR UNION UNIVERSITY SCHOOL OF PHARMACY JACKSON TENNESSEE USA. OUTLINE Structure of eye and different pathways of ocular administration Challenges for ocular delivery of proteins/peptides Formulation considerations Peptide transport systems in the eye Ocular …
https://link.springer.com/chapter/10.1007/978-3-319-95807-1_24
Oct 09, 2018 · This chapter addresses pros and cons of ocular delivery of peptides and proteins, significant features of their chemistry, potential and challenges associated with their local and systemic delivery, as well as different ways to attain better protein bioavailability and stability.Author: Rajiv Dahiya, Sunita Dahiya
https://www.semanticscholar.org/paper/Ocular-delivery-of-proteins-and-peptides%3A-and-novel-Mandal-Pal/2476b2b8e2ea396737243c7767c7c21f24a20bd0
Abstract The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides ...
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