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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nucleic-acid-delivery
Local Gene Delivery. Nucleic acids or nucleic acid delivery vehicles can be integrated with biomaterials for localized delivery. Examples of potential applications for this approach include controlled release of nucleic acids from stents for anti-restenosis treatment or incorporation of nucleic acids in tissue engineering scaffolds to guide new ...
https://www.ncbi.nlm.nih.gov/pubmed/25828594
Nucleic Acids Delivery Systems: A Challenge for Pharmaceutical Technologists. ... requires efficient achievement of the therapeutic target and also the safety and effectiveness of the pharmaceutical system. NA are not very efficient when administered alone, which means that the use of appropriate methods for in vivo transfection of these ...Author: Ana C. Silva, Carla M. Lopes, Jose M. Sousa Lobo, M. Helena Amaral
https://www.slideshare.net/shahrukhakash/nucleic-acid-62128335
May 18, 2016 · Composition of Nucleic Acids A nucleic acid polymer, polynucleotide,forms from the nucleotide monomers when the phosphate of one nucleotide bonds to the sugar of the next nucleotide. Resulting a repeating sugar-phosphate backbone with protruding nitrogenous bases. 7. Structure of Nucleotide 8. Types of Nucleic Acid 9.
https://www.sciencedirect.com/science/article/pii/S0169409X16302253
3. Virus-inspired nucleic acid delivery systems. Several viruses have been extensively exploited as gene delivery vectors for gene therapy. Besides the recently developed cytoplasmic viral delivery of miRNA, gene transfection and silencing is usually achieved through nuclear delivery of DNA by nuclear viruses.Author: Rong Ni, Junli Zhou, Naushad Hossain, Ying Chau
https://www.slideshare.net/RESHMASOMAN3/nucleic-acids-as-therapeutic-agents
Oct 20, 2016 · Nucleic acids as therapeutic agents 1. NUCLEIC ACIDS AS THERAPEUTIC AGENTS 2. Modern drug research aims to discover biologically active molecules that are absolutely specific to the molecular targets responsible for the disease progression.
https://reinekegroup.org/nucleic-acid-delivery
Delivery systems are needed to compact these sensitive payloads into nanostructures, protect nucleic acids from enzymatic damage during transport, promote cellular entry, and provide the possibility of targeting the delivery to specific tissue types and sites within the cell.
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · There are certainly multiple contributing factors, but the repurposing of advanced nucleic acid delivery systems for mRNA applications is an important facilitator of this phenomenon. LNPs are most advanced delivery systems for siRNA so it comes as no surprise that most of the clinical activity in mRNA medicine use these systems.Author: Matthew G. Stanton
https://ichorms.com/trigrid-devices/
Ichor’s TriGrid Delivery System is an investigational device designed to enhance the intracellular delivery of nucleic acid constructs in skeletal muscle. The system is comprised of three main components. The Pulse Stimulator controls the administration sequences and generates the electroporation pulses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088201/
Nov 01, 2016 · Nucleic Acid Protection. With any route of administration, nucleic acids are susceptible to chemical degradation and clearance from the body due to the presence of extracellular nucleases and the immune system (Abdelhady et al., 2003).While naked nucleic acid delivery is feasible, carrier-mediated delivery has the potential to be more efficient by protecting nucleic acids and chaperoning ...Author: James-Kevin Y. Tan, Drew L. Sellers, Binhan Pham, Suzie H. Pun, Philip J. Horner
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