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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nucleic-acid-delivery
Nucleic acid delivery systems are based on viral or nonviral methods [6]. Nonviral carrier (synthetic vector) delivery systems offer several advantages that have significantly advanced their development.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/nucleic-acid-delivery
Nucleic acid delivery presents unique challenges that could be entirely different compared to small molecules due to their molecular size, electric charge, and significant susceptibility to enzymatic degradation. However, some of the basic principles could be applied to both fields, which means specific carriers have been studied for delivery of small molecule drugs, genetic information, and mediators of …
https://reinekegroup.org/nucleic-acid-delivery
Nucleic Acid Delivery Nucleic acids are anionic biopolymers, which have promise as novel therapeutics for a number of acquired and inherited diseases. Polynucleotides of many different architectures have exceptional affinity and specificity for their intracellular targets.
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/delivery-of-nucleic-acids-using-polymers.html
Delivery vehicles for nucleic acids that will make it from bench to bedside need to possess biocompatibility and robust processes of assembly, conjugation, and purification.6 A broad variety of lipidbased vectors, polymers, biopolymers, dendrimers, polypeptides, and inorganic nanoparticles have been investigated...
https://www.sciencedirect.com/science/article/pii/S0168365920301929
Apr 06, 2020 · Nucleic acids have not been widely considered as an optimal material for drug delivery. Indeed, unmodified nucleic acids are enzymatically unstable, t…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399092/
Jul 17, 2012 · Nucleic acid delivery is a multistep process and inefficiencies at any stage result in a dramatic decrease in gene delivery or gene silencing. Despite this, the majority of studies investigating synthetic vectors focus solely on optimization of endosomal escape.Author: Juliane Nguyen, Francis C. Szoka
https://www.mdpi.com/journal/pharmaceuticals/special_issues/delivery_nucleic_acids
Nucleic acid delivery is difficult, and has proven to be even more challenging in vivo. We have not given up yet. We are still exploring new approaches and novel carriers on a regular basis. This Special Issue aims to include review and research papers that provide a comprehensive look at the most recent attempts in nucleic acid delivery ...
https://www.labome.com/method/Nucleic-Acid-Delivery-Lentiviral-and-Retroviral-Vectors.html
In recent years, retroviral and lentiviral vectors have become increasingly vital tools for the delivery of nucleic acids to many cell types in a variety of experimental systems. In addition to being important in laboratory settings for use in both in tissue culture and animal models, they have also been applied in clinical trials to treat genetic diseases.Author: Erin P O’Keefe
https://www.ncbi.nlm.nih.gov/pubmed/31356048
Aug 07, 2019 · In this study, an efficient gene-eluting stent was designed on the basis of one new nucleic acid delivery system to decrease the possibility of ISR. The reduction-responsive branched nucleic acid vector (SKP) with low cytotoxicity was first synthesized via ring-opening reaction.Author: Weijie Ye, Yiming Chen, Wenxiong Tang, Na Zhang, Zhonghao Li, Zunjing Liu, Bingran Yu, Fu-Jian Xu
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