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https://www.sciencedirect.com/science/article/pii/S0168365999002473
This formulation was shown to be at least 11.4% as effective as intraperitoneal injections of zinc insulin. This is very promising in that it shows that the development of an oral insulin (or oral protein) formulation based on thermoplastic nanospheres is possible.Author: Gerardo P Carino, Jules S Jacob, Edith Mathiowitz
https://www.researchgate.net/publication/12616944_Nanosphere_based_oral_insulin_delivery
The data suggest that this preparation of oral insulin can produce significant enteric absorption of the peptide, and that further investigation of agents that facilitate insulin absorption from ...
https://www.sciencedirect.com/science/article/abs/pii/S0168365999002473
Zinc insulin is successfully encapsulated in various polyester and polyanhydride nanosphere formulations using Phase Inversion Nanoencapsulation (PIN). The encapsulated insulin maintains its biological activity and is released from the nanospheres over a span of approximately 6 h.Author: Gerardo P Carino, Jules S Jacob, Edith Mathiowitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · A previous work showed a sustained reduction of glycemia in diabetic rats treated with insulin-loaded nanoparticles for 1 to 3 weeks. 52 Until now, different studies have been carried out developing polymeric-based nanoparticles for insulin oral delivery. The polymers used may differ from their origin if they are natural or synthetic.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.academia.edu/2342682/Nanosphere_based_oral_insulin_delivery
Nanosphere based oral insulin delivery
https://link.springer.com/article/10.1007/s11095-007-9367-4
Jun 19, 2007 · To evaluate the pharmacological activity of insulin-loaded alginate/chitosan nanoparticles following oral dosage in diabetic rats. Nanoparticles were prepared by ionotropic pre-gelation of an alginate core followed by chitosan polyelectrolyte complexation. In vivo activity was evaluated by measuring the decrease in blood glucose concentrations in streptozotocin induced, …Author: B. Sarmento, A. Ribeiro, F. Veiga, P. Sampaio, R. Neufeld, D. Ferreira
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