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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399092/
Jul 17, 2012 · A better understanding of the intracellular mechanisms and molecular bases of nucleic acid transfer, however, will enable a more rational and mechanism-based design of vectors. This knowledge will provide the missing pieces of the puzzle for effective nucleic acid delivery in animals and humans.Author: Juliane Nguyen, Francis C. Szoka
https://pubs.acs.org/doi/10.1021/ar3000162
The delivery of genes or RNA interference (RNAi) agents can increase or decrease the expression of virtually any protein in a cell, and this process opens the path for cures to most diseases that afflict humans. However, the high molecular weight, anionic nature, and instability of nucleic acids in the presence of enzymes pose major obstacles to their delivery and frustrates their use as human ...
https://www.researchgate.net/publication/221721601_Nucleic_Acid_Delivery_The_Missing_Pieces_of_the_Puzzle
None of these vectors has received FDA approval, which indicates that the current vectors do not yet have suitable properties for effective in vivo nucleic acid delivery. Nucleic acid delivery is ...
https://pubs.acs.org/doi/abs/10.1021/ar3000162
Mar 19, 2012 · The delivery of genes or RNA interference (RNAi) agents can increase or decrease the expression of virtually any protein in a cell, and this process opens the path for cures to most diseases that afflict humans. However, the high molecular weight, anionic nature, and instability of nucleic acids in the presence of enzymes pose major obstacles to their delivery and frustrates their use as human ...Author: Juliane Nguyen, Francis C. Szoka
http://europepmc.org/abstract/MED/22428908
Aug 01, 2012 · None of these vectors has received FDA approval, which indicates that the current vectors do not yet have suitable properties for effective in vivo nucleic acid delivery. Nucleic acid delivery is a multistep process and inefficiencies at any stage result in a …Author: Juliane Nguyen, Francis C. Szoka
https://www.ncbi.nlm.nih.gov/pubmed/22428908
Moved Permanently. The document has moved here.Author: Juliane Nguyen, Francis C. Szoka
https://pharmacy.ucsf.edu/francis-szoka
The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins.
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