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https://www.sciencedirect.com/science/article/pii/S0168365908007542
Nucleic acid delivery with chitosan and its derivatives. ... Nucleic acid (NA) therapy is an emerging field in medical and pharmaceutical sciences due to its potential for treating a variety of genetic disorders that have been incurable to date. ... Plasmid DNA delivery with chitosan and its derivatives 2.1. Overview of chitosan. Chitosan is a ...Author: Wing-Fu Lai, Marie Chia-Mi Lin
https://www.researchgate.net/publication/23682332_Nucleic_acid_delivery_with_chitosan_and_its_derivatives
As the polymer was described as displaying adjuvant properties also, chitosan and its derivatives are used in vaccine delivery systems, alone or in combination with other polymers.
https://www.sciencedirect.com/science/article/abs/pii/S0168365908007542
Nucleic acid delivery with chitosan and its derivatives. Author links open overlay panel Wing-Fu Lai Marie Chia-Mi Lin. Show moreAuthor: Wing-Fu Lai, Marie Chia-Mi Lin
https://www.researchgate.net/publication/319195506_Chitosan_and_its_Derivatives_as_Chemical_Drug_Delivery_Carriers
Chitosan, a natural biodegradable and biocompatible polysaccharide has received enormous attention as a carrier for drug delivery. Recently, nanoparticles of chitosan (CS) and its synthetic ...
https://iopscience.iop.org/article/10.1070/RCR4636/pdf
nucleic acid delivery by means of non-modified chitosan and discuss in detail the chemical strategies used for chitosan modification in order to enhance the transfection efficiency. The published reviews on this subject mainly deal with the biological and pharmacological aspects and barely concern the chemistry of chitosan and its derivatives. II.Author: Andrey S. Kritchenkov, Andrey S. Kritchenkov, Stanislav Andranovitš, Yury A. Skorik
http://www.eurekaselect.com/155047/article
Keywords:Aminopolysaccharide, chitosan, chitosan derivatives, drug delivery system, chemical modification. Abstract:Background: Chitosan (CS) is a nontoxic and biocompatible natural polysaccharide with great development potential in the delivery of chemical drugs. However, further applications of CS are limited due to its inherent insolubility ...Author: Lei Xing, Lina Du, Cheng-Qiong Luo, Tian-Jiao Zhou, Yong Zhu, Jia-Hui Gong, Yiguang Jin, Hu-Lin Jian...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680562/
Jul 15, 2019 · Nevertheless, due to their natural nautre, positively charged polysaccharides have led to the extensive use of chitosan for nucleic acid delivery . One of its main advantages is that its cationic nature enhances the electrostatic interaction with the negatively charged RNA, favoring the formation of stable polyplexes.Author: Inés Serrano-Sevilla, Álvaro Artiga, Scott G. Mitchell, Laura De Matteis, Jesús M. de la Fuente
https://core.ac.uk/display/37894273
Nucleic acid delivery with chitosan and its derivatives . By WF Lai and MCM Lin ... mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able to condense nucleic acids (NA) (both DNA and RNA) and protect them from nuclease degradation, its poor water solubility and low transfection efficacy have impeded its use as an NA carrier ...Author: Wing-Fu Lai, Marie Chia-Mi Lin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930495/
GC derivatives can be utilized for nucleic acid delivery in addition to the small-molecule chemodrugs. Gene therapy is a promising strategy to treat different diseases, for example, cancer, cystic fibrosis, adenosine deaminase deficiency, and Alzheimer’s disease [ 41 ].Author: Fengming Lin, Hao-Ran Jia, Fu-Gen Wu
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/delivery-of-nucleic-acids-using-polymers.html
Delivery of Nucleic Acids Using Polymers. By: Olivia Merkel, Material Matters, 2016, 8.3, 74. ... Delivery vehicles for nucleic acids that will make it from bench to bedside need to possess biocompatibility and robust processes of ... This leads to swelling and bursting of the lysosomes which release the polymer and nucleic acid into the cytosol.
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