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https://www.ncbi.nlm.nih.gov/pubmed/20420543
The objective of this study was to investigate the transfection efficiency of chitosan hydroxybenzotriazole (CS-HOBT) for in vitro nucleic acid delivery. The results revealed that CS-HOBT was able to condense with DNA/small interfering double-stranded RNA molecules (siRNA).Author: Praneet Opanasopit, Sunee Techaarpornkul, Theerasak Rojanarata, Tanasait Ngawhirunpat, Uracha Ruktan...
https://www.liebertpub.com/doi/10.1089/oli.2009.0227
The objective of this study was to investigate the transfection efficiency of chitosan hydroxybenzotriazole (CS-HOBT) for in vitro nucleic acid delivery. The results revealed that CS-HOBT was able to condense with DNA/small interfering double-stranded RNA molecules (siRNA).Author: Praneet Opanasopit, Sunee Techaarpornkul, Theerasak Rojanarata, Tanasait Ngawhirunpat, Uracha Ruktan...
https://www.researchgate.net/publication/43344826_Nucleic_Acid_Delivery_with_Chitosan_Hydroxybenzotriazole
Nucleic Acid Delivery with Chitosan Hydroxybenzotriazole. The objective of this study was to investigate the transfection efficiency of chitosan hydroxybenzotriazole (CS-HOBT) for in vitro nucleic acid delivery. The results revealed that CS-HOBT was able to condense with DNA/small interfering double-stranded RNA molecules (siRNA).
https://www.sciencedirect.com/science/article/pii/S0168365908007542
It is generally biocompatible, biodegradable, mucoadhesive, non-immunogenic and non-toxic. Although chitosan is able to condense nucleic acids (NA) (both DNA and RNA) and protect them from nuclease degradation, its poor water solubility and low transfection efficacy have impeded its use as an NA carrier.Author: Wing-Fu Lai, Marie Chia-Mi Lin
https://www.deepdyve.com/lp/elsevier/nucleic-acid-delivery-with-chitosan-hydroxybenzotriazole-yHCorVEhqn
Nucleic acid delivery with chitosan hydroxybenzotriazole Opanasopit, Praneet; Techaarpornkul, Sunee; Rojanarata, Theerasak; Ngawhirunpat, Tanasait; Ruktanonchai, Uracha Gene delivery is one of the critical steps for gene therapy. Nonviral delivery systems have been developed.
https://www.cambridge.org/core/journals/mrs-bulletin/article/translating-chitosan-to-clinical-delivery-of-nucleic-acidbased-drugs/9EE210866038D198C3061EC93F9D2E83
In this context, chitosan, a biocompatible and biodegradable polysaccharide, has been proposed as a promising alternative for the delivery of nucleic acid-based molecules. Here we present an overview of the state of the art of chitosan-based vectors for nucleic acid delivery and the most recent data on the in vivo testing of the proposed ...
https://www.sciencedirect.com/science/article/pii/S0169409X13001592
Non-viral nucleic acid (NA) delivery systems are also generally endowed with inherent formulation flexibility and lower manufacturing cost [4]. Moreover, interest in the field of non-viral vectors has gained new momentum recently due to the need for effective delivery systems for small interfering RNA...Author: Michael D. Buschmann, Abderrazzak Merzouki, Marc Lavertu, Marc Thibault, Myriam Jean, Vincent Darras
http://onlinelibrary.wiley.com/doi/10.1002/marc.200600152/abstract
Jun 28, 2006 · Summary: A chitosan-hydroxybenzotriazole (HOBt) aqueous solution prepared by simply mixing chitosan and HOBt in water provides an effective system to functionalize chitosan in an aqueous environment.
https://www.mdpi.com/2218-273X/10/4/553/pdf
Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells A. Katharina Kolonko 1,*, ... interact with and bind to negatively charged nucleic acids, mucins and sulphated glycosylaminoglycans in the glycocalyx and other drugs. This property, along with its
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