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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Non-viral vectors for siRNA delivery. Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration. In the case of delivery of DNA encoding for the short hairpin RNA (shRNA) by non-viral delivery systems, nuclear translocation of the DNA is often ...Author: Kun Gao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533807/
These artificial vectors are therefore seen as an attractive alternative for viral delivery systems. There are four main types of vectors that are convenient for non-viral siRNA delivery: 1) polymeric, 2) lipid, 3) protein and 4) dendrimeric nanocarrier delivery systems (Figure (Figure3). 3).Author: Ajit Thakur, Scott Fitzpatrick, Abeyat Zaman, Kapilan Kugathasan, Ben Muirhead, Gonzalo Hortelano, H...
https://www.sciencedirect.com/science/article/pii/S0168365915302832
Materials for non-viral intracellular delivery of messenger RNA therapeutics. ... (siRNAs) has recently been reported to have promise as non-viral delivery agents for mRNA. These materials include covalent conjugates, protamine complexes, nanoparticles based on lipids or polymers, and hybrid formulations. ... Again in the context of siRNA ...Author: Kevin J. Kauffman, Matthew J. Webber, Matthew J. Webber, Daniel G. Anderson
https://www.sciencedirect.com/science/article/pii/S0169409X07000208
Since charge complementarities aid complex formation, to bind negatively charged siRNA such carriers are typically positively charged. Non-viral siRNA transfection carriers can be categorized into lipid- and polycation-based ones. Lipofectamine 2000 , and cardiolipin analogues , have been successfully used for the delivery of siRNA.Author: Mini Thomas, James J. Lu, Jianzhu Chen, Alexander M. Klibanov
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Therefore, the development of siRNA-based viral and non-viral delivery systems are required to have an enhanced efficacy, improved stability, and minimized non-specific gene silencing such as off-target effects and immune responses. This chapter focuses on recent improvements in the non-viral siRNA delivery systems in cancer therapy.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
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