We have collected information about Non Viral Sirna Delivery To The Lung for you. Follow the links to find out details on Non Viral Sirna Delivery To The Lung.
https://www.sciencedirect.com/science/article/pii/S0169409X07000208
Delivery of siRNAs relevant to lung diseases has been attempted through multiple routes and using various carriers in animal models. This review focuses on the recent progress in non-viral delivery of siRNAs for the treatment of lung diseases, particularly infectious diseases.Author: Mini Thomas, James J. Lu, Jianzhu Chen, Alexander M. Klibanov
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low .Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.ncbi.nlm.nih.gov/pubmed/19606864
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Merkel OM(1), Beyerle A, Librizzi D, Pfestroff A, Behr TM, Sproat B, Barth PJ, Kissel T. Author information: (1)Department of Pharmaceutics and Biopharmacy, Philipps Universitat Marburg, Ketzerbach 63, 35032 Marburg, Germany.Author: Olivia M. Merkel, Andrea Beyerle, Damiano Librizzi, Andreas Pfestroff, Thomas M. Behr, Brian Sproat,...
https://www.researchgate.net/publication/6368742_Non-viral_siRNA_delivery_to_the_lung
As an alternative to viral vectors, non-viral vectors, including lipid and polymer-based vectors, have been generally used for the delivery of siRNAs to the lungs due to their reduced toxicity [57 ...
https://www.jstage.jst.go.jp/article/kona/34/0/34_2017005/_html/-char/ja/
Non-viral delivery of siRNA to the lung siRNA is a highly negative charged, hydrophilic, and large-sized (approximately 13.3 kDa) macromolecule that cannot cross …Author: Susanne R. Youngren-Ortiz, Nishant S. Gandhi, Laura España-Serrano, Mahavir B. Chougule, Mahavir B. ...
https://www.sciencedirect.com/science/article/pii/S0169409X14001306
Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low [10].Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration. In the case of delivery of DNA encoding for the short hairpin RNA (shRNA) by non-viral delivery systems, nuclear translocation of the DNA is often inadequate.Author: Kun Gao, Leaf Huang
https://pubag.nal.usda.gov/catalog/6850891
Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(l-histidine)-based multifunctional nanoplatform Author: ... growth retardation, histidine, lipids, lung neoplasms, nanoparticles, polyethylene glycol, small interfering RNA, sulfadimethoxine
https://www.sciencedirect.com/science/article/pii/S0169409X11000408
Non-viral delivery of siRNA to the lung A delivery vector is often required to facilitate the cellular delivery of siRNA as the highly charged, hydrophilic natures of the macromolecules make it unable to cross the biological membrane to reach its target sites.Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.researchgate.net/publication/262928803_siRNA_Delivery_to_the_lung_What's_new
Once loaded into RISC, the antisense strand of siRNA can be stable for weeks, thus reducing the frequency of dosing necessary for therapeutic gene knockdown. Of note, there are pulmonary-intrinsic barriers to efficient local siRNA delivery into the lung such as anatomy, cough,...
Searching for Non Viral Sirna Delivery To The Lung?
You can just click the links above. The data is collected for you.
