We have collected information about Non Viral Pulmonary Delivery Of Sirna for you. Follow the links to find out details on Non Viral Pulmonary Delivery Of Sirna.
https://pubs.acs.org/doi/10.1021/ar200110p
siRNA delivery targeting to the lung via agglutination-induced accumulation and clearance of cationic tetraamino fullerene. Scientific Reports 2015, 4 (1) DOI: 10.1038/srep04916. Daniel P Feldmann, Olivia M Merkel. The advantages of pulmonary delivery of therapeutic siRNA.Author: Olivia M. Merkel, Thomas Kissel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Non-viral vectors for siRNA delivery Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration. In the case of delivery of DNA encoding for the short hairpin RNA (shRNA) by non-viral delivery systems, nuclear translocation of the DNA is often inadequate.Author: Kun Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0169409X07000208
At a dose of 5 nmol of intranasal siRNA (averaging ∼ 70 μg for double-stranded siRNAs) per mouse, the siRNA against the P protein mRNA (referred to as siRNA#1) slashed pulmonary RSV titers 99.98%. Notably, the siRNA alone, i.e., free of transfection reagents, also significantly reduced pulmonary viral …Author: Mini Thomas, James J. Lu, Jianzhu Chen, Alexander M. Klibanov
https://www.researchgate.net/publication/51637253_Nonviral_Pulmonary_Delivery_of_siRNA
Request PDF Nonviral Pulmonary Delivery of siRNA RNA interference (RNAi) is an important part of the cell’s defenses against viruses and other foreign genes.
https://www.sciencedirect.com/science/article/pii/S0169409X11000408
Non-viral delivery of siRNA to the lung A delivery vector is often required to facilitate the cellular delivery of siRNA as the highly charged, hydrophilic natures of the macromolecules make it unable to cross the biological membrane to reach its target sites.Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.researchgate.net/publication/6368742_Non-viral_siRNA_delivery_to_the_lung
Commonly used non-viral vectors for siRNA delivery include lipids, polymers and peptides.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low [10].Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.sciencedirect.com/science/article/abs/pii/S0169409X11000408
The delivery systems need to be designed carefully in order to maximize the siRNA deposition to the diseased area of the airways. In most of the pulmonary siRNA therapy studies in vivo, siRNA was delivered either intratracheally or intranasally. Very limited work was done on the formulation of siRNA for inhalation which is believed to be the ...Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
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