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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095056/
Apr 15, 2011 · Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the leading non-viral vector for gene therapy. This vector combines the advantages of viruses and naked DNA. Here we review progress over the last 2 years in vector design, methods of delivery and safety that have supported its use in the clinic.Author: Elena L. Aronovich, R. Scott McIvor, Perry B. Hackett
https://www.ncbi.nlm.nih.gov/pubmed/21867398
The development of efficient and safe nonviral vectors armed with an integrating feature would thus greatly facilitate clinical gene therapy studies. The latest generation transposon technology based on the Sleeping Beauty (SB) transposon may potentially overcome some of these limitations.Author: Zoltán Ivics, Zsuzsanna Izsvák
https://www.researchgate.net/publication/51595640_Nonviral_Gene_Delivery_with_the_Sleeping_Beauty_Transposon_System
The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications.
https://www.liebertpub.com/doi/10.1089/hum.2011.143
Aug 25, 2011 · The Sleeping Beauty (SB) transposon system can efficiently and stably transfer genes into a variety of therapeutically relevant primary cell types, and is currently being tested in a first-in-man trial for B-cell lymphoma.Author: Zoltán Ivics, Zsuzsanna Izsvák
https://www.sciencedirect.com/science/article/pii/S0168952517301464
Optimized Vector Components for Enhanced Sleeping Beauty-Mediated Gene Delivery. Compared with the original version of the transposon (pT), attempts to improve the architecture of the transposon vector yielded several optimized variants (pT/2/3/4) 43, 44, 45, 46.The latest generation vector, pT4, was engineered to carry sequences optimized for transposase binding .Author: Partow Kebriaei, Zsuzsanna Izsvák, Suneel A. Narayanavari, Harjeet Singh, Zoltán Ivics
https://academic.oup.com/hmg/article/20/R1/R14/632060
Apr 01, 2011 · Abstract. Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the leading non-viral vector for gene therapy. This vector combines the advantages of viruses and naked DNA. Here we review progress over the last 2 years in vector design, methods of delivery and safety that have supported its use in the clinic.Author: Elena L. Aronovich, R. Scott McIvor, Perry B. Hackett
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30019-4
Apr 04, 2018 · The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications. However, efficient correction of hematopoietic stem and progenitor cells (HSPCs) with non-viral vector systems, including SB, demands further refinement of gene delivery techniques.Author: Marta Holstein, Cristina Mesa-Nuñez, Csaba Miskey, Elena Almarza, Valentina Poletti, Marco Schmeer, ...
https://www.cell.com/trends/genetics/fulltext/S0168-9525(17)30146-4
Nov 01, 2017 · The widespread clinical implementation of gene therapy requires the ability to stably integrate genetic information through gene transfer vectors in a safe, effective, and economical manner. The latest generation of Sleeping Beauty (SB) transposon vectors fulfills these requirements, and may overcome limitations associated with viral gene transfer vectors and transient nonviral gene delivery ...Author: Partow Kebriaei, Zsuzsanna Izsvák, Suneel A. Narayanavari, Harjeet Singh, Zoltán Ivics
https://experts.umn.edu/en/publications/the-sleeping-beauty-transposon-system-a-non-viral-vector-for-gene
T1 - The Sleeping Beauty transposon system. T2 - A non-viral vector for gene therapy. AU - Aronovich, Elena L. AU - McIvor, R. Scott. AU - Hackett, Perry B. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the leading nonviral vector for gene therapy.Author: Elena L. Aronovich, R. Scott McIvor, Perry B. Hackett
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