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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
The success of gene therapy is highly dependent on the delivery vector. Viral vectors have dominated the clinical trials in gene therapy for its relatively high delivery efficiency. However, the improvement of efficacy of non-viral vectors has lead to an increased number of products entering into clinical trials.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2010&volume=2&issue=1&spage=1
Nonviral Gene Therapy and its Delivery Systems Author(s): Haiching Ma , Scott L. Diamond . Institute for Medicine andEngineering, Department of Chemical Engineering, 1024 Vagelos ResearchLaboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
https://www.nature.com/articles/gt20175
Jan 17, 2017 · Recent advances in nanotechnology and material science have yielded many promising nonviral delivery systems, some of which were able to efficiently facilitate targeted in vivo delivery of IVT ...Author: S Guan, J Rosenecker
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687232/
Nov 27, 2012 · The viral gene delivery systems include lytic and nonlytic vectors for drug delivery. Inspite of its toxicity they are still preferred because of their long term expression, stability, and integrity. This review explores the recent developments and relevancy …
https://www.researchgate.net/publication/233841223_Viral_and_nonviral_delivery_systems_for_gene_delivery
Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell ...
https://www.seas.upenn.edu/~diamond/Pubs/2001_Ma_Curr_Pharm_Biotech.pdf
Current Pharmaceutical Biotechnology, 2001, 2, 1-17 Nonviral Gene Therapy and its Delivery Systems Haiching Ma- and Scott L. Diamond.•.~.. Institute for Medicine and Engineering, Department of Chemical Engineering, 1024 Vagelos
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Current gene delivery systems are divided into three categories: viral-based, non-viral based, and combined hybrid systems. Viral gene delivery systems consist of viruses that are modified to be replication-deficient which can deliver genes to the target cells to provide expression.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1402-1
Feb 15, 2018 · Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have ...Author: Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang W...
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Gene therapy is a promising new technique for treating many serious incurable diseases, such as cancer and genetic disorders. The main problem limiting the application of this strategy in vivo is the difficulty of transporting large, fragile and negatively charged molecules like DNA into the nucleus of the cell without degradation. The key to success of gene therapy is to create safe and ...Author: D. Ibraheem, A. Elaissari, H. Fessi
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