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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Physical methods of nonviral gene delivery. Physical methods applied for in vitro and in vivo gene delivery are based on making transient penetration in cell membrane by mechanical, electrical, ultrasonic, hydrodynamic, or laser-based energy so that DNA entrance into the targeted cells is facilitated.
https://www.ncbi.nlm.nih.gov/pubmed/28778715
Jun 01, 2017 · Gene therapy represents a promising cancer treatment featuring high efficacy and limited side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic polymers and lipid-based nonviral gene vectors have many advantages and have been extensively explored for cancer gene delivery, but their low gene-expression ...Author: Zhuxian Zhou, Xiangrui Liu, Dingcheng Zhu, Yue Wang, Zhen Zhang, Xuefei Zhou, Nasha Qiu, Xuesi Chen,...
https://www.sciencedirect.com/science/article/pii/S0168365915302649
During the earlier stages of gene therapy development, non-viral gene therapies were considered clinically unfeasible due to their poor gene delivery efficiency compared to viral delivery systems. Nonetheless, tremendous research efforts and advancements have brought nanoparticle-based non-viral gene delivery vectors one step closer to the clinic.Author: Marianna Foldvari, Ding Wen Chen, Nafiseh Nafissi, Daniella Calderon, Lokesh Narsineni, Amirreza Raf...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
The success of gene therapy is highly dependent on the delivery vector. Viral vectors have dominated the clinical trials in gene therapy for its relatively high delivery efficiency. However, the improvement of efficacy of non-viral vectors has lead to an increased number of products entering into clinical trials.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.sciencedirect.com/science/article/pii/S0169409X1730128X
Therefore, the primary challenge for gene therapy is to develop safe and efficient carriers to protect nucleic acids and facilitate their transfer to targeted cells at the targeted site. For in vivo gene delivery, the carrier/nucleic acid systems, named vectors, are categorized into two classes: viral vectors and nonviral vectors. Viruses such ...Author: Zhuxian Zhou, Xiangrui Liu, Dingcheng Zhu, Yue Wang, Zhen Zhang, Xuefei Zhou, Nasha Qiu, Xuesi Chen,...
https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Nonviral Gene Delivery with Cationic Glycopolymers. ... Reactive Oxygen Species (ROS)-Responsive Charge-Switchable Nanocarriers for Gene Therapy of Metastatic Cancer. ACS Applied Materials & Interfaces ... Cyclodextrin-Based Host–Guest Supramolecular Nanoparticles for Delivery: From Design to Applications. Accounts of Chemical Research ...Author: Meredith A. Mintzer, Eric E. Simanek
https://www.nature.com/articles/gt20175
Jan 17, 2017 · Because of its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of …Author: S Guan, J Rosenecker
https://www.springer.com/gp/book/9784431251224
Non-viral Gene Therapy Gene Design and Delivery. Editors: Taira, Kazunari, Kataoka, Kazunori, Niidome, Takuro (Eds.) Free Preview
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