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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gene-gun
In addition, the gene gun allows delivery of several genes simultaneously to the same target tissues, which enables studying the interaction among the gene products. Because the gene gun delivers a small amount of DNA efficiently, it is a promising approach for DNA vaccination.
https://www.researchgate.net/publication/26329886_Gene_Gun_Delivery_Systems_for_Cancer_Vaccine_Approaches
Another well-known physical gene delivery technique is the particle bombardment technique (particle-mediated gene transfer) in which gold particles (gene gun) or magnetic particles (magnetofection)...
https://www.sciencedirect.com/science/article/pii/S0264410X99003175
Gene gun immunisation propels DNA-coated particles at high velocity through the epidermis and into the dermis and is thought to achieve efficient transfection of a number of cell types, with intracellular delivery of the DNA-coated particle. Gene gun immunization has been shown to improve immune responses to viral antigens , and to luciferase .Author: Alice M Bennett, Robert J Phillpotts, Stuart D Perkins, Susan C Jacobs, E.Diane Williamson
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00594/full
Several methods have been explored to increase delivery efficiency and great progress has been made in the field of designing delivery vehicles form RNA vaccines (101–103). In addition to the physical methods of gene guns and electroporation, mRNA vaccines have been delivered into the cytoplasm by cationic lipids and polymers.Author: Cuiling Zhang, Giulietta Maruggi, Hu Shan, Junwei Li
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274812/
Nov 15, 2018 · More recently, the DNA vaccine delivery properties of orally applied bacteria, for example with regard to phagolysosomal escape have been improved by additional coating with NC . Compared with other sytemic routes of DNA vaccination, pulmonary application of aerolized DNA vaccines is a rather new approach [ 230 ].Author: Dominika Hobernik, Matthias Bros
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
For the vaccine developer, a consistent story emerging from over 15+ years of clinical development with plasmid based DNA vaccines collected across 100s of human clinical trials covering 1000s of healthy and diseased subjects spanning studies in infectious diseases, cancer, and gene therapy delivery is that of an excellent and consistently unremarkable safety profile.Author: Niranjan Y Sardesai, David B Weiner
https://www.who.int/immunization/research/meetings_workshops/PDVAC_2017_rNucleic_Acid_Vaccines_Graham.pdf
West Nile Virus VRC DNA Vaccine Ledgerwood et al. J Infect Dis. 2011;203:1396-1404 Ab (EC50) by RVP neutralization assay responses A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial. Ledgerwood JE, the VRC 303 Study Team, et al. May 15, 2011 6
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