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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gene-gun
In addition, the gene gun allows delivery of several genes simultaneously to the same target tissues, which enables studying the interaction among the gene products. Because the gene gun delivers a small amount of DNA efficiently, it is a promising approach for DNA vaccination.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Electroporation Enhanced DNA Vaccine Delivery. Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Over the last decade the technique has evolved from an experimental technique to now being used ...Author: Niranjan Y Sardesai, David B Weiner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC112106/
In this study, the potential of inducing mucosal immunity in cattle by immunization with a DNA vaccine was demonstrated. Cattle were immunized with a plasmid encoding bovine herpesvirus 1 (BHV-1) glycoprotein B, which was delivered with a gene gun either intradermally or intravulvomucosally.Author: B. I. Loehr, P. Willson, L. A. Babiuk, S. van Drunen Littel-van den Hurk
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
In a comparison study of the HPV DNA vaccine administered by different methods, electroporation has been shown to elicit the highest number of E7-specific cytotoxic CD8+T cells and greatest antitumor immune response compared to intramuscular injection and intradermal gene gun delivery [Best et al., 2009; Monie et al., 2010].Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
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